| Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep. | |
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MedLine Citation:
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PMID: 21195551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHOD: Merino ewes (n=28) randomly divided into three groups: (1) bronchial artery ligated and injured (injury+ligation group); (2) bronchial artery left intact and injured (injury+no ligation group); (3) bronchial artery ligated but not injured (no injury+ligation group) were subjected to a flame burn and inhalation injury under halothane anesthesia. Parameters were analyzed using Scheffe's post hoc test (P<0.05). All Groups were resuscitated with Ringer lactate solution and placed on a ventilator for 48h. RESULTS: Pulmonary gas exchange (PaO(2)/FiO(2)) improved in injury+ligation group. Further, obstruction score, an index of airway cast formation, significantly changed between injury+no ligation group compared to both ligation groups. CONCLUSION: Bronchial circulation plays a significant role in lung injury after B&S injury, and reduction of bronchial blood flow by bronchial artery ligation reduces bronchial exudates, resulting in improved gas exchange. |
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Authors:
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Naoki Morita; Perenlei Enkhbaatar; Dirk M Maybauer; Marc O Maybauer; Martin Westphal; Kazunori Murakami; Hal K Hawkins; Robert A Cox; Lillian D Traber; Daniel L Traber |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-30 |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 37 ISSN: 1879-1409 ISO Abbreviation: Burns Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-05-19 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: Netherlands |
Other Details:
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Languages: eng Pagination: 465-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and ISBI. All rights reserved. |
Affiliation:
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Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchial Arteries / physiopathology Burns / physiopathology* Exudates and Transudates / physiology Female Hemodynamics Oxygen / blood Pulmonary Circulation / physiology* Random Allocation Sheep, Domestic Smoke Inhalation Injury / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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GM060688/GM/NIGMS NIH HHS; P01 GM066312-01A2/GM/NIGMS NIH HHS; P01 GM066312-02/GM/NIGMS NIH HHS; P01 GM066312-03/GM/NIGMS NIH HHS; P01 GM066312-04/GM/NIGMS NIH HHS; P01 GM066312-05/GM/NIGMS NIH HHS; P01 GM066312-05S2/GM/NIGMS NIH HHS; P01-GM66312,/GM/NIGMS NIH HHS; R01 GM033324-06/GM/NIGMS NIH HHS; R01 GM033324-06S1/GM/NIGMS NIH HHS; R01 GM060688-01A1/GM/NIGMS NIH HHS; R01 GM060688-02/GM/NIGMS NIH HHS; R01 GM060688-03/GM/NIGMS NIH HHS; R01 GM060688-04/GM/NIGMS NIH HHS; R01 GM060688-05A2/GM/NIGMS NIH HHS; R01 GM060688-06/GM/NIGMS NIH HHS; R01 GM060688-07/GM/NIGMS NIH HHS; R01 GM060688-07S1/GM/NIGMS NIH HHS; R01 GM060688-08/GM/NIGMS NIH HHS; R01 GM060688-08S1/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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