| Impact of breast cancer chemotherapy on ovarian reserve: a prospective observational analysis by menstrual history and ovarian reserve markers. | |
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MedLine Citation:
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PMID: 18166178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether addition of taxanes to anthracycline and cyclophosphamide regimens impact ovarian function as assessed by menstrual history and ovarian reserve markers. DESIGN: Prospective observational analysis. SETTING: Large university fertility center. PATIENT(S): Forty-five women with a history of breast cancer of stages I-IIIA who either received anthracycline, cyclophosphamide, and paclitaxel (ACT) or received anthracycline with cyclophosphamide (AC). INTERVENTION(S): Menstrual histories were obtained at 6 months and at a mean of 28 months after chemotherapy. Early follicular phase FSH and E(2) samples were obtained at the second follow-up. MAIN OUTCOME MEASURE(S): Incidence of amenorrhea and abnormal laboratory values. RESULT(S): There was no statistically significant difference in the rates of amenorrhea at 6 months after chemotherapy (AC group, 41.7%; ACT group, 29%). At the second follow-up, a mean of 28 months after chemotherapy, there was a trend toward higher amenorrhea in the ACT patients (35.7%, vs. 9.1% in the AC group). When the ovarian markers were included, an additional eight menstruating patients were identified with abnormally elevated FSH or E(2) levels. CONCLUSION(S): We found no significant long- or short-term impact of taxanes on rates of amenorrhea. Future studies on the reproductive effects of chemotherapeutic agents should incorporate ovarian reserve markers, because menstrual history alone may underestimate the impact of these cytotoxic agents. |
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Authors:
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Andrea Reh; Ozgur Oktem; Kutluk Oktay |
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Publication Detail:
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Type: Journal Article Date: 2007-12-31 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1635-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / chemically induced*, metabolism, physiopathology Anthracyclines / administration & dosage Antineoplastic Combined Chemotherapy Protocols / adverse effects* Biological Markers / blood Breast Neoplasms / drug therapy* Cyclophosphamide / administration & dosage Estradiol / blood Female Follicle Stimulating Hormone / blood Humans Infertility, Female / chemically induced*, metabolism, physiopathology Menstruation / drug effects* Ovary / drug effects*, metabolism, physiopathology Paclitaxel / administration & dosage Prospective Studies Risk Assessment Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anthracyclines; 0/Biological Markers; 33069-62-4/Paclitaxel; 50-18-0/Cyclophosphamide; 50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone |
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