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Impact of boric acid exposure at different concentrations on testicular DNA and male rats fertility.
MedLine Citation:
PMID:  23301826     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The aim of this study was to investigate the consequences of exposure to three levels of boric acid on male rats reproduction, fertility, and progeny outcome, with emphasis on testicular DNA level and quality. ِAdult male rats (12 weeks old) were treated orally with 125, 250 and 500 mg/kg bwt/ day of boric acid for 60 days. The results indicated that boric acid administration at 125 mg/kg bwt had no adverse effects on fertility, sperm characteristics or prenatal development of the impregnated females. However, at dose 250 mg, boric acid treatment significantly increased serum nitric oxide, testosterone, estradiol levels and testicular boron and calcium levels and also significantly reduced serum arginase activity, sperm quality and testicular DNA content with minor DNA fragmentation. The impact of boric acid exposure at dose 250 mg on male rats fertility was translated into increases in pre-implantation loss with a resulting decrease in the number of live fetuses/ litter. In addition to the significant alteration of biochemical measurements, observed at dose 250 mg, administration of boric acid at 500 mg caused testicular atrophy, severe damage of spermatogenesis, spermiation failure and significant reduction of Mg and Zn testicular levels. None of the male rats, treated with 500 mg/kg bwt, could impregnate untreated females, suggesting the occurrence of definitive loss of fertility. In conclusion, boric acid impaired fertility, in a dose dependant manner, by targeting the highly proliferative cells, the germ cells, through decreasing DNA synthetic rate rather than the induction of DNA damage.
Authors:
Mai H El-Dakdoky; Hanan M F Abd El-Wahab
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Toxicology mechanisms and methods     Volume:  -     ISSN:  1537-6524     ISO Abbreviation:  Toxicol. Mech. Methods     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134521     Medline TA:  Toxicol Mech Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Zoology Department, Women College for Arts, Science and Education, Ain Shams University, 1 Asmaa Fahmey St., Heliopolis, Cairo 11757, Egypt. mhgawad11@yahoo.com.
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