Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry).

Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry).

MedLine Citation:	PMID: 18929693 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	The relation between body mass index (BMI) and waist-to-hip ratio (WHR) to clinical outcomes in patients with ST-segment elevation acute myocardial infarction (MI) has not been well described. As part of the Korean Acute MI Registry, we enrolled 3,734 eligible patients who were diagnosed with ST-segment elevation acute MI. The study population was categorized by BMI (into 4 groups according to the World Health Organization classification for the Asian population) and WHR (into 2 sets of 4 groups, 1 set for men and another for women, based on the INTERHEART study). Baseline characteristics and clinical outcomes were analyzed and compared among the BMI and WHR categories. Mean follow-up duration was 199 +/- 37 days. In the BMI category, underweight versus obese patients were older, were more likely to present with heart failure, and underwent guideline-based treatments less frequently. In the WHR category, the reverse trends were apparent for the latter factors except treatment-use frequencies. The highest mortality rate was observed in patients with the lowest BMI and the highest WHR. In an adjusted model, the highest WHR (hazard ratio 5.57, 95% confidence interval 1.53 to 12.29, p = 0.009) and the underweight (hazard ratio 2.88, 95% confidence interval 1.17 to 6.08, p = 0.021) categories within the 2 anthropometric indexes remained as mortality risk factors. In conclusion, the relation between obesity and prognosis after ST-segment elevation acute MI appears complex and should be further assessed in larger population-based cohort studies to determine the associations apparent in this study.

Authors:	Sang-Hee Lee; Jong-Seon Park; Woong Kim; Dong-Gu Shin; Young-Jo Kim; Dong-Su Kim; Dong-Ju Choi; Kyoo-Rok Han; Chong-Jin Kim; Myeong-Chan Cho; Shung-Chull Chae; Myung-Ho Jeong;
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Publication Detail:	Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2008-07-26
Journal Detail:	Title: The American journal of cardiology Volume: 102 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Oct
Date Detail:	Created Date: 2008-10-20 Completed Date: 2008-11-06 Revised Date: 2009-02-11
Medline Journal Info:	Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States
Other Details:	Languages: eng Pagination: 957-65 Citation Subset: AIM; IM
Affiliation:	Yeungnam University Hospital, Daegu, South Korea.
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MeSH Terms
Descriptor/Qualifier:	Aged Body Mass Index* Coronary Angiography Electrocardiography* Female Humans Incidence Korea / epidemiology Male Middle Aged Myocardial Infarction / diagnosis, epidemiology, etiology Obesity / complications, epidemiology Prevalence Prognosis Retrospective Studies Risk Factors Survival Rate Waist-Hip Ratio*
Investigator
Investigator/Affiliation:	Bon-Kwon Koo / ; Byung-Ok Kim / ; Chong-Jin Kim / ; Chong-Yun Rhim / ; Dong-Hoon Choi / ; Dong-Kyu Jin / ; Doo-Il Kim / ; Hyeon-Cheol Gwon / ; In-Ho Chae / ; In-Whan Seong / ; Jae-Young Rhew / ; Jang-Ho Bae / ; Jei-Keon Chae / ; Jeong-Gwan Cho / ; Jin-Man Cho / ; Jin-Yong Hwang / ; Jong-Hyun Kim / ; Jong-Seon Park / ; Jung-Han Yoon / ; Ju-Young Yang / ; Kee-Sik Kim / ; Keum-Soo Park / ; Ki-Bae Seung / ; Kyoo-Rok Han / ; Kyoung-Tae Jeong / ; Moo-Hyun Kim / ; Myeong-Chan Cho / ; Myung-Ho Jeong / ; Myoung-Yong Lee / ; Nae-Hee Lee / ; Seok-Kyu Oh / ; Seong-Wook Park / ; Seong-Woon Rha / ; Seung-Ho Hur / ; Seung-Jae Joo / ; Seung-Jea Tahk / ; Seung-Jung Park / ; Shung-Chull Chae / ; Soo-Joong Kim / ; Tae-Hoon Ahn / ; Taek-Jong Hong / ; Yang-Soo Jang / ; Young-Jo Kim / ; Young-Keun Ahn / ; Young-Youp Koh / ; Wook-Sung Chung /
Comments/Corrections
Comment In:	Am J Cardiol. 2009 Feb 1;103(3):435 [PMID: 19166705 ]

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