Document Detail

Impact of body mass index on markers of left ventricular thickness and mass calculation: results of a pilot analysis.
MedLine Citation:
PMID:  15725154     Owner:  NLM     Status:  MEDLINE    
Specific correlations between body mass index (BMI) and left ventricular (LV) thickness have been conflicting. Accordingly, we investigated if a particular correlation exists between BMI and echocardiographic markers of ventricular function. METHODS: A total of 122 patients, referred for routine transthoracic echocardiography, were included in this prospective pilot study using a 3:1 randomization approach. Patient demographics were obtained using a questionnaire. RESULTS: Group I consisted of 80 obese (BMI was >30 kg/m2), Group II of 16 overweight (BMI between 26 and 29 kg/m2), and Group III of 26 normal BMI (BMI < 25 kg/m2) individuals. No difference was found in left ventricular wall thickness, LV end-systolic cavity dimension, fractional shortening (FS), or pulmonary artery systolic pressure (PASP) among the groups. However, mean LV end-diastolic cavity dimension was greater in Group I (5.0 +/- 0.9 cm) than Group II (4.6 +/- 0.8 cm) or Group III (4.4 +/- 0.9 cm; P < 0.006). LV mass indexed to height(2.7) was also significantly larger in Group I (61 +/- 21) when compared to Group III (48 +/- 19; P < 0.001). Finally, left atrial diameter (4.3 +/- 0.7 cm) was also larger (3.8 +/- 0.6 and 3.6 +/- 0.7, respectively; P < 0.00001). DISCUSSION: We found no correlation between BMI and LV wall thickness, FS, or PASP despite the high prevalence of diabetes and hypertension in obese individuals. However, obese individuals had an increased LV end-diastolic cavity dimension, LV mass/height(2.7), and left atrial diameter. These findings could represent early markers in the sequence of cardiac events occurring with obesity. A larger prospective study is needed to further define the sequence of cardiac abnormalities occurring with increasing BMI.
Ranjini Krishnan; Richard J Becker; Lisa M Beighley; Angel López-Candales
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  22     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Blood Pressure / physiology
Body Height / physiology
Body Mass Index*
Diabetes Complications / ultrasonography
Heart Atria / pathology,  ultrasonography
Heart Ventricles / pathology,  ultrasonography*
Hypertension / ultrasonography
Middle Aged
Myocardial Contraction / physiology
Obesity / pathology,  physiopathology,  ultrasonography
Pilot Projects
Prospective Studies
Pulmonary Artery / physiology
Sex Factors
Ventricular Function, Left / physiology
Ventricular Function, Right / physiology
Ventricular Pressure / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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