Document Detail

Impact of body-composition methodology on the composition of weight loss and weight gain.
MedLine Citation:
PMID:  23422922     Owner:  NLM     Status:  Publisher    
Background/Objectives:We intended to (i) to compare the composition of weight loss and weight gain using densitometry, deuterium dilution (D(2)O), dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI) and the four-compartment (4C) model and (ii) to compare regional changes in fat mass (FM), fat-free mass (FFM) and skeletal muscle as assessed by DXA and MRI.Subjects/Methods:Eighty-three study participants aged between 21 and 58 years with a body mass index range of 20.2-46.8 kg/m(2) had been assessed at two different occasions with a mean follow-up between 23.5 and 43.5 months. Body-weight changes within < 3% were considered as weight stable, a gain or a loss of >3% of initial weight was considered as a significant weight change.Results:There was a considerable bias between the body-composition data obtained by the individual methods. When compared with the 4C model, mean bias of D(2)O and densitometry was explained by the erroneous assumption of a constant hydration of FFM, thus, changes in FM were underestimated by D(2)O but overestimated by densitometry. Because hydration does not normalize after weight loss, all two-component models have a systematic error in weight-reduced subjects. The bias between 4C model and DXA was mainly explained by FM% at baseline, whereas FFM hydration contributed to additional 5%. As to the regional changes in body composition, DXA data had a considerable bias and, thus, cannot replace MRI.Conclusions:To assess changes in body composition associated with weight changes, only the 4C model and MRI can be used with confidence.European Journal of Clinical Nutrition advance online publication, 20 February 2013; doi:10.1038/ejcn.2013.35.
M Pourhassan; B Schautz; W Braun; C-C Gluer; A Bosy-Westphal; M J Müller
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-20
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  -     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany.
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