| Impact of body-composition methodology on the composition of weight loss and weight gain. | |
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MedLine Citation:
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PMID: 23422922 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Objectives:We intended to (i) to compare the composition of weight loss and weight gain using densitometry, deuterium dilution (D(2)O), dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI) and the four-compartment (4C) model and (ii) to compare regional changes in fat mass (FM), fat-free mass (FFM) and skeletal muscle as assessed by DXA and MRI.Subjects/Methods:Eighty-three study participants aged between 21 and 58 years with a body mass index range of 20.2-46.8 kg/m(2) had been assessed at two different occasions with a mean follow-up between 23.5 and 43.5 months. Body-weight changes within < 3% were considered as weight stable, a gain or a loss of >3% of initial weight was considered as a significant weight change.Results:There was a considerable bias between the body-composition data obtained by the individual methods. When compared with the 4C model, mean bias of D(2)O and densitometry was explained by the erroneous assumption of a constant hydration of FFM, thus, changes in FM were underestimated by D(2)O but overestimated by densitometry. Because hydration does not normalize after weight loss, all two-component models have a systematic error in weight-reduced subjects. The bias between 4C model and DXA was mainly explained by FM% at baseline, whereas FFM hydration contributed to additional 5%. As to the regional changes in body composition, DXA data had a considerable bias and, thus, cannot replace MRI.Conclusions:To assess changes in body composition associated with weight changes, only the 4C model and MRI can be used with confidence.European Journal of Clinical Nutrition advance online publication, 20 February 2013; doi:10.1038/ejcn.2013.35. |
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Authors:
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M Pourhassan; B Schautz; W Braun; C-C Gluer; A Bosy-Westphal; M J Müller |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-20 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: - ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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