| Impact of blood collection devices on clinical chemistry assays. | |
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MedLine Citation:
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PMID: 19822139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood collection devices interact with blood to alter blood composition, serum, or plasma fractions and in some cases adversely affect laboratory tests. Vascular access devices may release coating substances and exert shear forces that lyse cells. Blood-dissolving tube additives can affect blood constituent stability and analytical systems. Blood tube stoppers, stopper lubricants, tube walls, surfactants, clot activators, and separator gels may add materials, adsorb blood components, or interact with protein and cellular components. Thus, collection devices can be a major source of preanalytical error in laboratory testing. Device manufacturers, laboratory test vendors, and clinical laboratory personnel must understand these interactions as potential sources of error during preanalytical laboratory testing. Although the effects of endogenous blood substances have received attention, the effects of exogenous substances on assay results have not been well described. This review will identify sources of exogenous substances in blood specimens and propose methods to minimize their impact on clinical chemistry assays. |
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Authors:
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Raffick A R Bowen; Glen L Hortin; Gyorgy Csako; Oscar H Ota?ez; Alan T Remaley |
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Publication Detail:
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Type: Historical Article; Journal Article; Review Date: 2009-10-12 |
Journal Detail:
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Title: Clinical biochemistry Volume: 43 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 4-25 Citation Subset: IM |
Copyright Information:
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Copyright 2009 The Canadian Society of Clinical Chemists. All rights reserved. |
Affiliation:
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Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA. rbowen@stanfordmed.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants Biological Assay Blood Coagulation Blood Specimen Collection / history, instrumentation*, methods Catheterization Chemistry, Clinical* / instrumentation, methods Disinfectants History, 20th Century Humans Laboratory Techniques and Procedures* Needles Specimen Handling / instrumentation, methods Surface-Active Agents Syringes |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Disinfectants; 0/Surface-Active Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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