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Impact of birth weight at term on rates of emergency room visits and hospital admissions following vaccination at 2 months of age.
MedLine Citation:
PMID:  21907256     Owner:  NLM     Status:  Publisher    
BACKGROUND: Birth weight of children born at term may theoretically be associated with risk of adverse events from immunization. METHODS: We analyzed data on children born between April 1st 2002 and March 31st 2009 in the province of Ontario. Using the self-controlled case series design, we examined the risk of the combined endpoint of emergency room visit and hospital admission in the immediate three days post vaccination at 2 months of age compared to a control period 9-18 days after vaccination. In term children, we conducted 4 comparisons of relative incidence (RI) of events: (1) 4 lower birth weight quintiles compared to the largest quintile (2) SGA10 infants compared to non SGA10 infants, (3) low birth weight infants (<2500g) compared to non low birth weight infants and (4) SGA10 infants vaccinated before 60 days compared to those vaccinated after 60 days. RESULTS: There was a significant trend towards increasing relative incidence of the combined endpoint with decreasing birth weight quintile (p=0.016). There was an increased relative incidence of events in SGA10 versus non SGA10 infants (RI 1.25 (95% CI 1.09-1.44)) and in SGA10 children vaccinated before 60 days of age compared to after 60 days of age (RI 1.57 (95% CI 1.14-2.18)). No significant effect was observed in low birth weight children. The impact of birth weight was primarily mediated through an increase in ER visits in the 24h following vaccination. CONCLUSION: Lower birth weight appears to be correlated with an increased risk of emergency room visits within 24h of vaccination. The absolute risk is small and there was no impact on admissions or death.
Kumanan Wilson; Steven Hawken; Jeffrey C Kwong; Shelley Deeks; Doug Manuel; Kirsten Holdt Henningsen; Natasha S Crowcroft
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-7
Journal Detail:
Title:  Vaccine     Volume:  -     ISSN:  1873-2518     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Canada; ICES@Uottawa, Ottawa Hospital Research Institute, University of Ottawa, Canada; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
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