| Impact of beam quality on megavoltage radiotherapy treatment techniques utilizing gold nanoparticles for dose enhancement. | |
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MedLine Citation:
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PMID: 23302438 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study determines the optimal clinical scenarios for gold nanoparticle dose enhancement as a function of irradiation conditions and potential biological targets using megavoltage x-ray beams. Four hundred and eighty clinical beams were studied for different potential cellular or sub-cellular targets. Beam quality was determined based on a 6 MV linac with and without a flattening filter for various delivery conditions. Dose enhancement ratios DER = D(GNP)/D(water) were calculated for all cases using the GEANT4 Monte Carlo code and the CEPXS/ONEDANT radiation transport deterministic code. Dose enhancement using GEANT4 agreed with CEPXS/ONEDANT. DER for unflattened beams is ∼2 times larger than for flattened beams. The maximum DER values were calculated for split-IMRT fields (∼6) and for out-of-field areas of an unflattened linac (∼17). In-field DER values, at the surface of gold nanoparticles, ranged from 2.2 to 4.2 (flattened beam) and from 3 to 4.7 (unflattened beams). For a GNP cluster with thicknesses of 10 and 100 nm, the DER ranges from 14% to 287%. DER is the greatest for split-IMRT, larger depths, out-of-field areas and/or unflattened linac. Mapping of a GNP location in tumor and normal tissue is essential for efficient and safe delivery of nanoparticle-enhanced radiotherapy. |
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Authors:
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Panagiotis Tsiamas; Bo Liu; Fulya Cifter; Wilfred F Ngwa; Ross I Berbeco; Constantin Kappas; Kiriaki Theodorou; Karen Marcus; Mike G Makrigiorgos; Erno Sajo; Piotr Zygmanski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 58 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: 451-464 Citation Subset: - |
Affiliation:
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Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA. Medical Physics Department, Medical School, University of Thessaly, Larisa 4100, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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