Document Detail

Impact of baseline renal function on outcomes of renal artery stenting in hypertensive patients.
MedLine Citation:
PMID:  19878369     Owner:  NLM     Status:  MEDLINE    
Renal artery stenting may improve blood pressure (BP) and renal function in resistant hypertension patients; however, benefit may differ depending on the degree of renal dysfunction. The authors analyzed 67 consecutive patients receiving stenting for obstructive renal artery disease between 2002 and 2005. Patients were categorized as normal or mildly impaired according to estimated glomerular filtration rate (eGFR) (> or =60 mL/min/1.73 m(2)), moderately impaired (eGFR 30 to 59 mL/min/1.73 m(2)), and severely impaired (eGFR <30 mL/min/1.73 m(2)). In patients with eGFR > or =60, systolic BP did not significantly improve from baseline. However, in patients with an eGFR between 30 and 59 mL/min/1.73 m(2), systolic BP decreased by 12 mm Hg at 6 months (P=.02) and 14 mm Hg at 12 months (P=.01). Greater benefit was observed in patients with eGFR <30 mL/min/1.73 m(2), with a 16 mm Hg (P=.10) and 21 mm Hg (P=.02) decrease at 6 and 12 months, respectively. Renal function was stable across all groups. Renal artery stenting reduced BP and produced greatest benefit in patients with baseline impaired renal function.
Gregory M Singer; Michael S Remetz; Jeptha P Curtis; John F Setaro
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  11     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615-20     Citation Subset:  IM    
Copyright Information:
2009 Wiley Periodical, Inc.
Department of Internal Medicine, Yale University of School of Medicine, New Haven, CT 06520-8017, USA.
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MeSH Terms
Aged, 80 and over
Blood Pressure / physiology
Creatinine / blood
Glomerular Filtration Rate / physiology
Hypertension, Renal / physiopathology,  therapy*
Kidney / blood supply,  physiopathology*
Renal Artery / physiopathology*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:

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