| Impact of baseline level of 7-ketocholesterol on the rate of coronary reintervention in coronary artery disease patients--results of an observational study with questionnaire-based follow up. | |
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MedLine Citation:
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PMID: 11208404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The aim of study was to assess the relation between plasma level of one of the oxysterols--7-ketocholesterol and angiographically evidenced coronary artery disease. MATERIAL AND METHODS: We measured plasma level of 7-ketocholesterol, malondialdehyde, total cholesterol, HDL cholesterol, triglycerides, erythrocyte activity of superoxide dismutase in 233 patients who previously underwent coronary angiography for diagnosis of coronary artery disease. The follow-up of patients (28 months) was done on basis of questionnaires sent out to them. RESULTS: We found that the subgroup of patients with 7-ketocholesterol above the median value (62 ng/mL) has higher rate of coronary reintervention (8/54 pts vs. 5/43 pts in 7-ketocholesterol below 62 ng/mL respectively, p = 0.284 Log-rank test). The finding was more pronounced, yet insignificant, in the subgroup of patients who underwent primary PTCA (6/19 pts vs. 2/20 pts, p = 0.1 Log-rank test). There were 3 patients in high 7-ketocholesterol subgroup who entered the study with previously undergone primary coronary intervention. There were not such patients in low 7-ketocholesterol subgroup. 4 deaths were observed in high 7-ketocholesterol subgroup, and one in low 7-ketocholesterol subgroup (they were predominantly not of cardiovascular origin). CONCLUSIONS: We failed to find a significant relation between 7-ketocholesterol and coronary artery disease, though there is a trend of such relation in patients who undergo PTCA, evidenced by a slightly higher number of repeated revascularizations among patients with high 7-ketocholesterol. The study indicates the areas of further studies with agents capable of lowering oxysterols and assessing also other end points. |
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Authors:
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A Tomasik; W Jacheć; B Skrzep-Poloczek; C Wojciechowska; R Tarnawski; J Wodniecki; L Poloński; K Szczurek-Katański |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 6 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2000 Jul-Aug |
Date Detail:
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Created Date: 2001-03-05 Completed Date: 2001-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: 751-8 Citation Subset: IM |
Affiliation:
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2nd Department of Cardiology, Silesian Medical University, ul. M. Curie-Skłodowskiej 10, 41-800 Zabrze, Poland. kl2karz@infomed.slam.katowice.pl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Biological Markers / blood Case-Control Studies Coronary Disease / blood*, etiology, therapy* Cross-Sectional Studies Female Follow-Up Studies Humans Ketocholesterols / blood* Lipids / blood Male Middle Aged Models, Cardiovascular Questionnaires Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Ketocholesterols; 0/Lipids; 566-28-9/7-ketocholesterol; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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