| Impact of baroreflex on venous return surface. | |
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MedLine Citation:
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PMID: 22255289 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Although Guyton's concept of venous return (VR) revolutionized circulatory physiology, the pulmonary circulation is invisible in its original framework. Since the pulmonary circulation is critical in left heart failure, we characterized the VR as a surface described by right (P(RA)) and left atrial (P(LA)) pressures and demonstrated that the VR surface was capable of representing mechanics of pulmonary as well as systemic circulation. However how baroreflex impacts the VR surface remains unknown. Methods/Results: In 8 dogs, we isolated the carotid sinuses and replaced both ventricles with pumps. We varied cardiac output, shifted blood distribution between the systemic and pulmonary circulation at carotid sinus pressures (CSP) of 100 or 140 mmHg. The coefficient of determination of the VR surface ranged 0.96-0.99 indicating how flat the surface is. Increasing CSP decreased maximum VR (233±27 vs. 216±33 ml/kg/min, p<0.05), whereas did not change the slopes of VR along P(RA) or P(LA) axes. Conclusions: Baroreflex parallel shifts the VR surface, thereby stressed volume, without changing its slopes. |
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Authors:
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Takafumi Sakamoto; Yoshinori Murayama; Atsushi Tanaka; Kazuo Sakamoto; Tomoyuki Tobushi; Keita Saku; Kazuya Hosokawa; Ken Onitsuka; Takeo Fujino; Kenji Sunagawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 2011 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 4295-6 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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