| Impact of atrazine on chlorpyrifos toxicity in four aquatic vertebrates. | |
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MedLine Citation:
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PMID: 16944040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrazine has been shown previously to potentiate chlorpyrifos toxicity in selected invertebrates. This study examined interactions of atrazine and chlorpyrifos in four aquatic vertebrates. Organisms were exposed to binary mixtures of atrazine and chlorpyrifos during toxicity bioassays. Inhibition of cholinesterase (ChE) enzyme activity and chlorpyrifos uptake kinetics were also examined with and without atrazine exposure. Atrazine alone did not affect organisms at concentrations up to 5000 microg/L; however, the presence of atrazine at 1000 microg/L did result in a significant increase in the acute toxicity of chlorpyrifos in Xenopus laevis. Mixed results were encountered with Pimephales promelas; some bioassays showed greater than additive toxicity, while others showed an additive response. No effect of atrazine on chlorpyrifos toxicity was observed for Lepomis macrochirus and Rana clamitans. Atrazine did not affect ChE activity or chlorpyrifos uptake rates, indicating that these toxicodynamic and toxicokinetic parameters may not be related to the mechanism of atrazine potentiation of chlorpyrifos toxicity. Based on the results of this study, it does not appear that a mixture toxicity of atrazine and chlorpyrifos at environmentally relevant concentrations presents a risk to the vertebrate organisms examined in this study. |
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Authors:
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M N Wacksman; J D Maul; M J Lydy |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2006-08-30 |
Journal Detail:
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Title: Archives of environmental contamination and toxicology Volume: 51 ISSN: 0090-4341 ISO Abbreviation: Arch. Environ. Contam. Toxicol. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-16 Completed Date: 2006-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0357245 Medline TA: Arch Environ Contam Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 681-9 Citation Subset: IM |
Affiliation:
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Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrazine / toxicity* Chlorpyrifos / pharmacokinetics, toxicity* Cholinesterases / metabolism Cyprinidae Dose-Response Relationship, Drug Drug Synergism Herbicides / toxicity* Insecticides / toxicity* Perciformes Ranidae Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Herbicides; 0/Insecticides; 1912-24-9/Atrazine; 2921-88-2/Chlorpyrifos; EC 3.1.1.8/Cholinesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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