Document Detail

Impact of assisted hatching on the outcome of intracytoplasmic sperm injection: a prospective, randomized clinical trial and pregnancy follow-up.
MedLine Citation:
PMID:  16580371     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the overall effect of assisted hatching (AH) on the implantation, pregnancy, and live birth rates in women undergoing intracytoplasmic sperm injection (ICSI) cycles; and to determine the effect of AH on the cytogenetic outcome (chromosomal constitution) of pregnancy. DESIGN: Prospective, randomized study. SETTING: Academic research environment. PATIENT(S): A total of 172 couples were enrolled in the study. INTERVENTION(S): Assisted hatching was carried out on day-3 ICSI embryos. MAIN OUTCOME MEASURE(S): Implantation, clinical pregnancy, and live birth rates; cytogenetic analysis of abortuses and umbilical cord blood samples from newborns. RESULT(S): Biochemical, clinical, and ongoing pregnancy rates were not significantly different between the AH and control groups. The implantation rate was higher in the AH group than in the control group (16% vs. 8%), especially in women aged > or =35 years. Postnatal umbilical cord blood samples were collected and cytogenetically analyzed from 39 live births (20 from the AH group, 19 from the control group). Two abnormal karyotypes were found (one AH, one control). There were seven spontaneous losses during the study interval. Six of the abortuses underwent cytogenetic study (five AH, one control), and four were found to have an abnormal karyotype (three AH, one control). CONCLUSION: We found that AH improves implantation rates of ICSI cycles and seems to be most effective in women aged > or =35 years. A larger sample size is needed to determine whether AH improves the take-home-baby rate. Assisted hatching did not affect the rate of chromosomal abnormalities in live births in this study.
Sai Ma; Timothy Rowe; Basil Ho Yuen
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-03-09
Journal Detail:
Title:  Fertility and sterility     Volume:  85     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-03     Completed Date:  2006-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  895-900     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
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MeSH Terms
Embryo Implantation*
Follow-Up Studies
Infant, Newborn
Infertility, Female / epidemiology,  therapy
Live Birth / epidemiology*
Maternal Age
Pregnancy Rate*
Prospective Studies
Reproductive Techniques, Assisted* / trends
Sperm Injections, Intracytoplasmic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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