Document Detail

Impact of arterial stiffness reduction on urinary albumin excretion during antihypertensive treatment: the Japan morning Surge-1 study.
MedLine Citation:
PMID:  20485195     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: There has been no report investigating the impact of the arterial stiffness reduction induced by antihypertensive medications on the improvement of target organ damage in hypertension. The aim of this study was to assess the association of the change in pulse wave velocity (PWV) with that in urinary albumin excretion as a measure of renal damage. METHODS: We studied 404 treated hypertensive patients (mean age, 70.5 +/- 9.5 years), who were allocated to either an active treatment group (doxazosin and atenolol when needed) or a control group. Blood pressure, urinary albumin-to-creatinine ratio (UACR), and brachial-ankle PWV (baPWV) were measured at baseline and after 6 months of treatment. RESULTS: In the total population, home/office SBP, UACR, and baPWV decreased significantly from the baseline. In multivariate regression analyses, DeltabaPWV was significantly associated with DeltaUACR, independent of Deltahome SBP (beta = 0.21, P < 0.001). When the patients were divided into a group with DeltabaPWV of at least 0 cm/s (positive DeltaPWV) and a group with DeltabaPWV of less than 0 cm/s (negative DeltaPWV), the reduction of UACR was greater in the latter group, even after adjustment for the covariates including the change in home SBP. These results were essentially the same when office SBP was entered in place of home SBP, and similar both in the active treatment group and the control group. CONCLUSION: These findings suggest that the arterial stiffness reduction induced by antihypertensive medications is associated with the improvement of renal damage, independent of home/office SBP reduction.
Yoshio Matsui; Kazuo Eguchi; Seiichi Shibasaki; Joji Ishikawa; Satoshi Hoshide; Kazuyuki Shimada; Kazuomi Kario;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1752-60     Citation Subset:  IM    
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
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MeSH Terms
Albuminuria / chemically induced*,  urine
Ankle Brachial Index
Antihypertensive Agents / therapeutic use*
Atenolol / therapeutic use*
Blood Flow Velocity / drug effects
Brachial Artery / drug effects,  physiopathology
Cohort Studies
Doxazosin / therapeutic use*
Drug Therapy, Combination
Elasticity / drug effects
Hypertension / drug therapy*,  physiopathology,  urine
Pulsatile Flow / drug effects
Retrospective Studies
Reg. No./Substance:
0/Antihypertensive Agents; 29122-68-7/Atenolol; 74191-85-8/Doxazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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