| Impact of aortic stenting on peripheral vascular function and daytime systolic blood pressure in adult coarctation. | |
| | |
MedLine Citation:
|
PMID: 17686804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To determine the relation of ambulatory systolic blood pressure to aortic obstruction and more extensive vascular dysfunction, assessed by central aortic, peripheral conduit arterial and resistance vessel function. METHODS: 12 adults (5 native, 7 recoarctation) were studied before, and 2 weeks and 6 months after aortic stenting. Systolic blood pressure was measured during normal daily living by 24-hour ambulatory monitoring. Central aortic function was assessed by pulse wave analysis (augmentation index). Brachial artery flow-mediated dilatation and dilatation in response to 25 mug of sublingual glyceryl trinitrate was assessed by ultrasound to measure peripheral conduit arterial and resistance vessel function. Baseline vascular measures were compared with those of 12 matched controls. RESULTS: Patients had a higher augmentation index, impaired endothelium-dependent and -independent dilatation, and forearm vascular resistance (p<0.02). After successful gradient relief by stenting, daytime ambulatory systolic blood pressure (151 (134, 166) mm Hg vs 138 (130, 150) mm Hg, p = 0.01) and the augmentation index (26 (15, 34) vs 23 (13, 30), p = 0.03) fell progressively over 6 months, but did not completely normalise. Endothelium-dependent and -independent dilatation, and forearm vascular resistance remained unchanged and impaired. CONCLUSION: Relief of aortic obstruction is associated with improvement in central aortic function and results in reduction of daytime ambulatory systolic blood pressure. Peripheral vascular dysfunction, however, remains unchanged and may contribute to residual hypertension. |
| | |
Authors:
|
S S M Chen; A E Donald; C Storry; J P Halcox; P Bonhoeffer; J E Deanfield |
Related Documents
:
|
15199304 - Determination of central aortic systolic and pulse pressure from the radial artery pres... 10980584 - Favourable effects on arterial wave reflection and pulse pressure amplification of addi... 725524 - Duodenal pressure activity recorded by an intraluminal electrical transducer in man. 16282364 - Physiology of the esophageal pressure transition zone: separate contraction waves above... 1067414 - Relationship between the width of the occlusal table and pressures under dentures durin... 92354 - Topical application of epinephrine during bronchoscopy in barbiturate-halothane-anaesth... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-08 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 94 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-06-16 Completed Date: 2008-10-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 919-24 Citation Subset: AIM; IM |
Affiliation:
|
Grown-up Congenital Heart Unit, The Heart Hospital, University College London, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aortic Coarctation / complications, physiopathology, surgery* Blood Pressure Monitoring, Ambulatory Brachial Artery / physiopathology, ultrasonography Female Follow-Up Studies Forearm / blood supply Humans Hypertension / etiology*, physiopathology Male Peripheral Vascular Diseases / etiology*, physiopathology Prospective Studies Stents* Vascular Resistance Vasodilation |
| Grant Support | |
ID/Acronym/Agency:
|
//British Heart Foundation |
| Comments/Corrections | |
Comment In:
|
Heart. 2008 Jul;94(7):828-9
[PMID:
18552218
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of patient-prosthesis mismatch on exercise capacity in patients after bioprosthetic aortic va...
Next Document: Assessment of the anatomic regurgitant orifice in aortic regurgitation: a clinical magnetic resonanc...