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Impact of antihypertensive treatment on left ventricular systolic dyssynchrony in treatment-naïve hypertensive patients.
MedLine Citation:
PMID:  22418240     Owner:  NLM     Status:  Publisher    
Dyssynchrony is common in asymptomatic patients with hypertension. We sought to investigate the impact of antihypertensive treatment on dyssynchrony in patients with hypertension. A total of sixty patients who had uncomplicated hypertension that had never been treated (treatment-naïve hypertensive patients) underwent echocardiographic evaluations of left ventricular (LV) dyssynchrony at baseline and after a 6-month treatment with antihypertensive drugs. The measured parameters were as follows: (1) the s.d. of 12 LV-segment time-to-peak systolic velocities (Ts-SD12), and (2) the maximal difference between peak systolic velocities of any 2 of the 12 segments (Ts-Max). Patients with Ts-SD12 33 ms or Ts-Max 100 ms were regarded as having LV systolic dyssynchrony. Patients with systolic dyssynchrony (group 1, n=29) and without systolic dyssynchrony (group 2, n=31) were compared. Among the patients in group 1, antihypertensive treatment significantly improved LV systolic dyssynchrony (ΔTs-SD12, -13.1 ms; P<0.001 and ΔTs-Max, -34.0 ms; P=0.003), whereas it did not demonstrate additional benefit among group 2 patients. The change in LV systolic dyssynchrony was significantly associated with changes in the mean annulus E' velocity, mean annulus S' velocity and mean annulus E'/A' ratio, but not with changes in blood pressure and LV mass index. It is likely that chronic antihypertensive treatment could reverse the LV systolic dyssynchrony and simultaneously improve subclinical systolic and diastolic function in patients with hypertension and LV systolic dyssynchrony.Hypertension Research advance online publication, 15 March 2012; doi:10.1038/hr.2012.28.
Beom-June Kwon; Sung-Won Jang; Kyu-Young Choi; Dong-Bin Kim; Eun-Joo Cho; Sang-Hyun Ihm; Ho-Joong Youn; Tai-Ho Rho; Jae-Hyung Kim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-15
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  -     ISSN:  1348-4214     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, St Paul's Hospital, Seoul, Republic of Korea.
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