Document Detail


Impact of anabolic androgenic steroids on adolescent males.
MedLine Citation:
PMID:  20096713     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anabolic androgenic steroid (AAS) use increased dramatically among adolescent males. This review focuses on studies using animal models of AAS exposure during adolescence which is a hormonally sensitive developmental period. AAS exposure during this critical period has wide-ranging consequences, including increased dendritic spine density, altered brain serotonin levels and escalated aggression in response to physical provocation. Human data suggest that AAS induces indiscriminate and unprovoked aggression often described as "'roid rage". However, animal studies indicate that the behavioral impact of AAS is modulated by experiential and social contingencies, a perceived provocation, and the chemical composition of the AAS. The AAS, testosterone increases aggression in juvenile and adult male rats when physically provoked. In contrast, stanzolol, inhibits aggression in both juvenile and adult male rats, even when physically provoked. Nandrolone has minimal effects on aggression, unless preceded by attack training. Exposure to AAS during adolescence may have a host of unintended bio-behavioral consequences. Yet, the perception of harmlessness surrounds AAS use. The perception of harmlessness is promoted by the availability of AAS especially through internet pharmacies. The perception of acceptability is reflected in current cultural ethics that no longer condemn cheating to obtain personal achievement or success. A prevailing conviction is that although AAS are illegal they are not really bad. Reduction of the availability of AAS to adolescents requires ardent legislative and legal intervention. The problem of acceptability can be addressed by educating adolescents about the short-term and long-term effects of AAS on brain and behavior, to increase awareness of the potential consequences of AAS use that apply directly to them.
Authors:
Augustus R Lumia; Marilyn Y McGinnis
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-01-22
Journal Detail:
Title:  Physiology & behavior     Volume:  100     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adolescent Behavior / drug effects*,  psychology
Adolescent Psychology
Adult
Age Factors
Aggression / drug effects,  psychology
Anabolic Agents / adverse effects*
Androgens / adverse effects*
Animals
Brain / drug effects*,  metabolism
Dendritic Spines / drug effects
Humans
Male
Nandrolone / adverse effects*
Rats
Serotonin / metabolism
Social Behavior
Testosterone / adverse effects*
Time Factors
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Androgens; 434-22-0/Nandrolone; 50-67-9/Serotonin; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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