Document Detail


Impact of amygdala, orbital frontal, or hippocampal lesions on threat avoidance and emotional reactivity in nonhuman primates.
MedLine Citation:
PMID:  19348528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors measured the effects of bilateral amygdaloid, orbital frontal, or hippocampal lesions on emotional reactivity and passive avoidance in rhesus monkeys (Macaca mulatta). Animals were presented with 8 neutral or 8 aversive objects, each paired with a highly preferred food reward. Sham-operated control animals displayed heightened defensive behaviors and typically would not approach or retrieve the food when paired with a potential predator (coiled rubber snake), 2 conditioned aversive stimuli for laboratory-housed monkeys (a capture net and leather handling gloves), and 1 object displaying a threatening social signal (direct eye contact from a human-like doll). Animals with amygdala lesions, but not hippocampal or orbital frontal lesions, showed less tension-related behaviors and diminished passive avoidance of the rubber snake and its matched neutral item (a coiled piece of hose) relative to control animals. All operated groups displayed normal patterns of behavior toward conditioned and socially aversive objects. These results expand our understanding of how the primate brain evaluates reward and threat, and indicate a highly specialized role for the amygdala in mediating passive avoidance and emotional reactivity to potentially life-threatening stimuli.
Authors:
Christopher J Machado; Andy M Kazama; Jocelyne Bachevalier
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Emotion (Washington, D.C.)     Volume:  9     ISSN:  1528-3542     ISO Abbreviation:  Emotion     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-07     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125678     Medline TA:  Emotion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-63     Citation Subset:  IM    
Copyright Information:
(c) 2009 APA, all rights reserved.
Affiliation:
Department of Neurobiology and Anatomy, University of Texas Health Science Center, USA. cjmachado@ucdavis.edu
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MeSH Terms
Descriptor/Qualifier:
Amygdala / pathology*
Animals
Escape Reaction / physiology*
Fear / physiology*
Frontal Lobe / pathology*
Hippocampus / pathology*
Macaca mulatta
Magnetic Resonance Imaging
Male
Random Allocation
Grant Support
ID/Acronym/Agency:
HD-35471/HD/NICHD NIH HHS; MH-58846/MH/NIMH NIH HHS; MH-63577/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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