| Impact of amlodipine or ramipril treatment on left ventricular mass and carotid intima-media thickness in nondiabetic hemodialysis patients. | |
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MedLine Citation:
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PMID: 20722555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Left ventricular hypertrophy (LVH) and atherosclerosis are frequently observed in uremic patients and they have appeared as an independent predictor of cardiovascular morbidity and mortality. The aim of this study was to compare the effects of ramipril and amlodipine on left ventricular mass index (LVMI) and carotid intima-media thickness (CIMT) in nondiabetic hypertensive hemodialysis patients. METHODS: A total of 112 hemodialysis (HD) patients were included in this study. Patients were randomly allocated to receive ramipril or amlodipine for 1 year. Blood pressure (BP) measurements, LVMI, and CIMT were assessed at baseline and 6-month intervals. Biochemical parameters and inflammatory markers were also determined at the initiation and during the study period. RESULTS: Similar BP decrease was observed in treatment groups. During follow-up, LVMI and CIMT progressed likewise in both treatment groups despite BP control. However, subgrouping analyses due to the pattern of left ventricular geometry showed that LVMI in patients with eccentric LVH increased, whereas LVMI decreased in subjects with concentric LVH under antihypertensive treatment. DISCUSSION: BP control with ramipril or amlodipine could not provide adequate protection for development or progression of atherosclerosis and eccentric type of LVH in nondiabetic HD patients. |
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Authors:
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Rahmi Yilmaz; Bulent Altun; Serkan Kahraman; Necla Ozer; Devrim Akinci; Cetin Turgan |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Renal failure Volume: 32 ISSN: 1525-6049 ISO Abbreviation: Ren Fail Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: England |
Other Details:
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Languages: eng Pagination: 903-12 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Medical Faculty of Hacettepe University, Ankara, Turkey. drrahmiy@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amlodipine / pharmacology, therapeutic use* Antihypertensive Agents / pharmacology, therapeutic use* Atherosclerosis / etiology, prevention & control*, ultrasonography Carotid Arteries / drug effects, ultrasonography Female Heart Ventricles / drug effects, ultrasonography Humans Hypertension / complications, drug therapy, ultrasonography Hypertrophy, Left Ventricular / etiology, prevention & control*, ultrasonography Kidney Failure, Chronic / complications, therapy, ultrasonography Male Middle Aged Ramipril / pharmacology, therapeutic use* Renal Dialysis* Stroke Volume Tunica Intima / drug effects, ultrasonography Tunica Media / drug effects, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 87333-19-5/Ramipril; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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