Document Detail


Impact of amino acid imbalance on brain amines.
MedLine Citation:
PMID:  3119509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The brain levels of serotonin (5-HT), norepinephrine (NE) and dopamine (DM) were studied in amino acid imbalance, induced in rats by feeding them an 8% casein diet supplemented with 0.3% L-threonine. In addition, tryptophan hydroxylase (TPH) and monoamine oxidase (MAO) activities in the brain were measured. The studies revealed that induction of amino acid imbalance decreased the brain levels of 5-HT and NE, and increased the DM level significantly. These changes in the amine levels were found to be accompanied by increases in the activities of TPH and MAO of brain. It has been suggested that the enhanced activity of brain TPH in threonine imbalance was probably brought about by a conformational change of the enzyme protein and might be an adaptive response to the low level of 5-HT in the brain due to increased MAO activity. The increased brain DM level in threonine imbalance could be ascribed to enhanced entry of tyrosine in the catecholamine anabolic pathway, while the diminished brain NE level under the same condition might result from its increased degradation or diminished conversion of DM to NE due to supposedly inhibition of DM-beta-hydroxylase.
Authors:
B B Dalal; A K Chatterjee; U Sadhu
Related Documents :
16824509 - Changes in brain interleukin-1beta following the coadministration of norfloxacin with b...
3098919 - Biotin transport through the blood-brain barrier.
6619869 - Nitrogen metabolism of the human brain.
6148379 - Amino acid transport by synaptosomes isolated from post mortem human brain.
10518579 - Selective expression of the large neutral amino acid transporter at the blood-brain bar...
10930569 - Simvastatin does not normalize very long chain fatty acids in adrenoleukodystrophy mice.
5032529 - Metabolism of steroid and amino acid moieties of conjugated bile acids in man. i. choly...
6487649 - Fatty acid incorporation increases the affinity of muscarinic cholinergic receptors for...
20032599 - Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycoside...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  57     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-04     Completed Date:  1988-01-04     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Affiliation:
Department of Physiology, Calcutta University, College of Science, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Brain / metabolism*
Diet
Dopamine / metabolism*
Male
Monoamine Oxidase / metabolism
Norepinephrine / metabolism*
Rats
Serotonin / metabolism*
Threonine
Tryptophan Hydroxylase / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 72-19-5/Threonine; EC 1.14.16.4/Tryptophan Hydroxylase; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Difference in serum ascorbate in two species of Callithricidae.
Next Document:  A large-scale, orthogonal network of microfibril bundles in the corneal stroma.