Document Detail

Impact of amino acid imbalance on brain amines.
MedLine Citation:
PMID:  3119509     Owner:  NLM     Status:  MEDLINE    
The brain levels of serotonin (5-HT), norepinephrine (NE) and dopamine (DM) were studied in amino acid imbalance, induced in rats by feeding them an 8% casein diet supplemented with 0.3% L-threonine. In addition, tryptophan hydroxylase (TPH) and monoamine oxidase (MAO) activities in the brain were measured. The studies revealed that induction of amino acid imbalance decreased the brain levels of 5-HT and NE, and increased the DM level significantly. These changes in the amine levels were found to be accompanied by increases in the activities of TPH and MAO of brain. It has been suggested that the enhanced activity of brain TPH in threonine imbalance was probably brought about by a conformational change of the enzyme protein and might be an adaptive response to the low level of 5-HT in the brain due to increased MAO activity. The increased brain DM level in threonine imbalance could be ascribed to enhanced entry of tyrosine in the catecholamine anabolic pathway, while the diminished brain NE level under the same condition might result from its increased degradation or diminished conversion of DM to NE due to supposedly inhibition of DM-beta-hydroxylase.
B B Dalal; A K Chatterjee; U Sadhu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  57     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-04     Completed Date:  1988-01-04     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Department of Physiology, Calcutta University, College of Science, India.
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MeSH Terms
Amino Acids / metabolism*
Brain / metabolism*
Dopamine / metabolism*
Monoamine Oxidase / metabolism
Norepinephrine / metabolism*
Serotonin / metabolism*
Tryptophan Hydroxylase / metabolism
Reg. No./Substance:
0/Amino Acids; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 72-19-5/Threonine; EC Hydroxylase; EC Oxidase

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