Document Detail

Impact of aldosterone-producing adenoma on cardiac structures in echocardiography.
MedLine Citation:
PMID:  24319340     Owner:  NLM     Status:  Publisher    
BACKGROUND: Primary aldosteronism (PA) is a most common cause of secondary hypertension. In PA, left ventricular hypertrophy (LVH) is more progressive than in any other cause of hypertension. Aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) are major subtypes of PA. However there is little information concerned with differences of cardiac structures between these two subtypes.
METHODS: We reviewed echocardiographic findings in 46 patients with PA. All patients had a positive screen test and subtypes of PA were confirmed by adrenal vein sampling. Subjects consisted of 20 patients with APA (APA group, 52.4 ± 10.8 years) and 26 patients with IHA (IHA group, 56.2 ± 9.5 years). We investigated differences of cardiac structures and functions in the left atrium and ventricle between the APA group and IHA group.
RESULTS: In terms of clinical characteristics, the height and duration of hypertension were greater and serum potassium concentration and BMI were lower in the APA group than in the IHA group. Plasma aldosterone concentration (PAC) and PAC to plasma renin activity ratio were higher in the APA group than in the IHA group. In echocardiographic assessment, the left atrial volume, left ventricular end-diastolic and end-systolic diameters, left ventricular mass (LVM), and prevalence of LVH were greater in the APA group than in the IHA group. Multiple linear regression analysis revealed that the diagnosis of APA independently correlated with left atrial volume, left ventricular end-diastolic diameter, and LVM.
CONCLUSIONS: We demonstrated that differences of cardiac structures between the APA group and IHA group existed. In APA, left atrial enlargement and LVH were more prominent than in IHA.
Takayuki Hidaka; Tsuguka Shiwa; Yuichi Fujii; Kenji Nishioka; Hiroto Utsunomiya; Ken Ishibashi; Naoya Mitsuba; Yoshihiro Dohi; Noboru Oda; Kensuke Noma; Satoru Kurisu; Yukiko Nakano; Hideya Yamamoto; Takafumi Iishida; Yukihito Higashi; Yasuki Kihara
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-5
Journal Detail:
Title:  Journal of echocardiography     Volume:  11     ISSN:  1349-0222     ISO Abbreviation:  J Echocardiogr     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101263153     Medline TA:  J Echocardiogr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  123-129     Citation Subset:  -    
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences and Health, Kasumi 1-2-3, Minami-ku, Hiroshima Japan.
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