| Impact of adventitial neovascularisation on atherosclerotic plaque composition and vascular remodelling in a porcine model of coronary atherosclerosis. | |
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MedLine Citation:
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PMID: 20542785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: There is little in vivo data in regards to the impact of adventitial neovascularisation on vascular remodelling and plaque composition. Using a porcine model of coronary atherosclerosis, we aimed to determine the impact of adventitial neovascularisation on plaque composition and vascular remodelling evaluated by IVUS. METHODS AND RESULTS: Coronary atherosclerosis was induced by adventitial delivery of lipids and a high cholesterol diet. At termination all vessels were analysed using IVUS to determine the degree of remodelling of each individual segment containing atherosclerotic lesions. Then, each segment was correlated with its correspondent histological frame for plaque composition and neovessel density. A total of 57 atherosclerotic lesions at different stages of development were analysed. The total neovessel count (TNC) correlated to the degree of plaque burden (15.6+/-7.2 TNC in <40% stenosis versus 35.7+/-14.0 TNC in >60% stenosis, p<0.01) and to the amount of intra-plaque collagen (32.4+/-14.1%, lower TNC tertile versus 47.5+/-8.9% upper TNC tertile, p< 0.01). The amount of intra-plaque SMC content inversely correlated with the TNC (49.7+/-18.9% versus 36.4+/-14.4%, lower versus upper tertiles, p<0.05). Plaques with the highest TNC showed higher remodelling indexes by IVUS (0.89+/-0.32 in lower TNC tertile versus 1.36+/-0.73 in upper TNC tertile, p<0.05) and higher macrophage cell content (161.42+/-157.6 in lower TNC tertile versus 340.6+/-127.2 in upper TNC tertile, p<0.05) compared to non-remodelled segments. CONCLUSIONS: Adventitial neovascularisation is more prominent in positively remodelled segments and appears to be associated to SMC loss, increase collagen deposition and localised macrophage infiltration. |
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Authors:
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Carlos L Alviar; Armando Tellez; David Wallace-Bradley; Gabriel Lopez-Berestein; Angela Sanguino; Daryl G Schulz; Angela Builes; Christie M Ballantyne; Chao-Yuh Yang; Greg L Kaluza; Juan F Granada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Volume: 5 ISSN: 1969-6213 ISO Abbreviation: EuroIntervention Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251040 Medline TA: EuroIntervention Country: France |
Other Details:
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Languages: eng Pagination: 981-8 Citation Subset: IM |
Affiliation:
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Skirball Center for Cardiovascular Research, New York, NY, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collagen / metabolism Connective Tissue / blood supply* Coronary Stenosis / metabolism, physiopathology*, ultrasonography Coronary Vessels / metabolism, physiopathology*, ultrasonography Disease Models, Animal Disease Progression Immunohistochemistry Macrophages / pathology Myocytes, Smooth Muscle / pathology Neovascularization, Pathologic / metabolism, physiopathology*, ultrasonography Severity of Illness Index Swine Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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