| Impact of adjunctive tirofiban administration on myocardial perfusion and mortality in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction. | |
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MedLine Citation:
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PMID: 15886794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have shown that suboptimal myocardial perfusion may be observed despite optimal epicardial recanalisation in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI), resulting in unfavourable outcome. The aim of the current study was to evaluate the benefits in myocardial perfusion and mortality from adjunctive tirofiban administration in patients undergoing primary angioplasty for (STEMI). Atotal of 1,969 patients with STEMI treated by primary angioplasty represent the population of the current study. All clinical, angiographic and follow-up data were prospectively collected. Tirofiban was administrated in 481 patients (24.4%) (all before angioplasty). Tirofiban was associated with less distal embolisation (11.7% vs 16.1%, p = 0.048), better postprocedural MBG 3 (50.9% vs 39.7%, adjusted p < 0.0001) and a significant reduction in 1-year mortality (3% vs 6.4%, adjusted p = 0.045). The benefits in mortality were confirmed in all subgroups identified according to the quartiles of the propensity score. This study shows that, when compared to control group, adjunctive tirofiban before primary angioplasty for STEMI is associated with better myocardial perfusion and a reduction in 1-year mortality. |
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Authors:
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Giuseppe De Luca; Jaap J Smit; Nicolette Ernst; Harry Suryapranata; Jan Paul Ottervanger; Jan C A Hoorntje; Jan-Henk E Dambrink; A T Marcel Gosslink; Menko-Jan de Boer; Arnoud W J van 't Hof |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 93 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-11 Completed Date: 2005-08-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 820-3 Citation Subset: IM |
Affiliation:
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Department of Cardiology, ISALA Klinieken, Zwolle, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiography Angioplasty, Transluminal, Percutaneous Coronary / methods* Female Fibrinolytic Agents / pharmacology* Follow-Up Studies Heart / drug effects* Humans Male Middle Aged Myocardial Infarction / mortality*, therapy* Myocardial Reperfusion Myocardium / pathology* Perfusion Stroke / therapy Time Factors Tyrosine / analogs & derivatives*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 144494-65-5/tirofiban; 55520-40-6/Tyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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