Document Detail

The impact of vitamin D status on periodontal surgery outcomes.
MedLine Citation:
PMID:  21555774     Owner:  NLM     Status:  MEDLINE    
Vitamin D regulates calcium and immune function. While vitamin D deficiency has been associated with periodontitis, little information exists regarding its effect on wound healing and periodontal surgery outcomes. This longitudinal clinical trial assessed outcomes of periodontal surgery and teriparatide administration in vitamin-D-sufficient and -insufficient individuals. Forty individuals with severe chronic periodontitis received periodontal surgery, daily calcium and vitamin D supplements, and self-administered teriparatide or placebo for 6 wks to correspond with osseous healing time. Serum 25(OH)D was evaluated at baseline, 6 wks, and 6 mos post-surgery. Clinical and radiographic outcomes were evaluated over 1 yr. Placebo patients with baseline vitamin D deficiency [serum 25(OH)D, 16-19 ng/mL] had significantly less clinical attachment loss (CAL) gain (-0.43 mm vs. 0.92 mm, p < 0.01) and probing depth (PPD) reduction (0.43 mm vs. 1.83 mm, p < 0.01) than vitamin-D-sufficient individuals. Vitamin D levels had no significant impact on CAL and PPD improvements in teriparatide patients at 1 yr, but infrabony defect resolution was greater in teriparatide-treated vitamin-D-sufficient vs. -deficient individuals (2.05 mm vs. 0.87 mm, p = 0.03). Vitamin D deficiency at the time of periodontal surgery negatively affects treatment outcomes for up to 1 yr. Analysis of these data suggests that vitamin D status may be critical for post-surgical healing. ( number, CT00277706).
J D Bashutski; R M Eber; J S Kinney; E Benavides; S Maitra; T M Braun; W V Giannobile; L K McCauley
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-09
Journal Detail:
Title:  Journal of dental research     Volume:  90     ISSN:  1544-0591     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-09-12     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1007-12     Citation Subset:  D; IM    
Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, 1011 N. University Ave., Room 3349, Ann Arbor, MI 48109, USA.
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MeSH Terms
24,25-Dihydroxyvitamin D 3 / blood
Bone Density Conservation Agents / pharmacology
Chronic Periodontitis / metabolism*,  surgery*
Linear Models
Longitudinal Studies
Middle Aged
Teriparatide / pharmacology
Treatment Outcome
Vitamin D / metabolism,  pharmacology*
Vitamin D Deficiency / metabolism*
Vitamins / metabolism,  pharmacology*
Wound Healing / drug effects*
Grant Support
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Vitamins; 1406-16-2/Vitamin D; 40013-87-4/24,25-Dihydroxyvitamin D 3; 52232-67-4/Teriparatide

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