Document Detail


Impact of tissue volume and purification on clinical autologous islet transplantation for the treatment of chronic pancreatitis.
MedLine Citation:
PMID:  22305295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autologous islet transplantation after total pancreatectomy is an excellent treatment for painful chronic pancreatitis. Traditionally, islets have been isolated without purification; however, purification is applied when the tissue volume is large. Nevertheless, the impact of tissue volume and islet purification on clinical outcomes of autologous islet transplantation has not been well examined. We analyzed 27 cases of autologous islet transplantation performed from October 2006 to January 2011. After examining the relationship between tissue volume and portal pressure at various time points, we compared islet characteristics and clinical outcomes between cases with complications (complication group) and without (noncomplication group), as well as cases with purification (purification group) and without (nonpurification group). Tissue volume significantly correlated with maximum (R = 0.61), final (R = 0.53), and delta (i.e., difference between base and maximum; R = 0.71) portal pressure. The complication group had a significantly higher body mass index, tissue volume, islet yield, and portal pressure (maximum, final, delta), suggesting that complications were associated with high tissue volume and high portal pressure. Only one of four patients (25%) in the complication group became insulin free, whereas 11 of 23 patients (49%) in the noncomplication group became insulin free with smaller islet yields. The purification group had a higher islet yield and insulin independence rate but had similar final tissue volume, portal pressure, and complication rates compared with the nonpurification group. In conclusion, high tissue volume was associated with high portal pressure and complications in autologous islet transplantation. Islet purification effectively reduced tissue volume and had no negative impact on islet characteristics. Therefore, islet purification can reduce the risk of complications and may improve clinical outcome for autologous islet transplantation when tissue volume is large.
Authors:
Shinichi Matsumoto; Morihito Takita; Masayuki Shimoda; Koji Sugimoto; Takeshi Itoh; Daisuke Chujo; Jeffery A SoRelle; Yoshiko Tamura; Ana M Rahman; Nicholas Onaca; Bashoo Naziruddin; Marlon F Levy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-02
Journal Detail:
Title:  Cell transplantation     Volume:  21     ISSN:  1555-3892     ISO Abbreviation:  Cell Transplant     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-06-25     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Islets of Langerhans Transplantation / adverse effects,  methods*
Male
Organ Size / physiology
Pancreatitis, Chronic / surgery*
Retrospective Studies
Grant Support
ID/Acronym/Agency:
1R21DK090513-01/DK/NIDDK NIH HHS; R21 DK090513/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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