| Impact of Time-of-Flight and Point-Spread-Function in SUV Quantification for Oncological PET. | |
| | |
MedLine Citation:
|
PMID: 23334123 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Accuracy in the quantification of the SUV is a critical point in PET because proper quantification of tumor uptake is essential for therapy monitoring and prognosis evaluation. Recent advances such as time-of-flight (TOF) and point-spread-function (PSF) reconstructions have dramatically improved detectability. However, first experiences with these techniques have shown a consistent tendency to measure markedly high SUV values, bewildering nuclear medicine physicians and referring clinicians. PURPOSE: We investigated different reconstruction and quantification procedures to determine the optimum protocol for an accurate SUV quantification in last generation PET scanners. METHODS: Both phantom and patient images were evaluated. A complete set of experiments was performed using a body phantom containing 6 spheres with different background levels and contrasts. Whole-body FDG PET/CT of 20 patients with breast and lung cancer was evaluated. One hundred five foci were identified by 2 experienced nuclear medicine physicians.Each acquisition was reconstructed both with classical and advanced (TOF, PSF) reconstruction techniques. Each sphere and each in vivo lesion was quantified with different parameters as follows: SUVmax, SUVmean, and SUV50 (mean within a 50% isocontour). RESULTS: This study has confirmed that quantification with SUVmax produces important overestimation of metabolism in new generation PET scanners. This is a relevant result because, currently, SUVmax is the standard parameter for quantification. SUV50 has been shown as the best alternative, especially when applied to images reconstructed with PSF + TOF. CONCLUSIONS: SUV50 provides accurate quantification and should replace SUVmax in PET tomographs incorporating advanced reconstruction techniques. PSF + TOF reconstruction is the optimum for both detection and accurate quantification. |
| | |
Authors:
|
Elena Prieto; Inés Domínguez-Prado; María José García-Velloso; Iván Peñuelas; José Angel Richter; Josep Maria Martí-Climent |
Related Documents
:
|
3775633 - Postoperative radiographic appearance of intracranial hemostatic gelatin sponge. 23304143 - Analysis of criteria for mri diagnosis of tmj disc displacement and arthralgia. 6828723 - Intrahepatic vascular territories shown by computed tomography (ct). the value of ct in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nuclear medicine Volume: 38 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 103-9 Citation Subset: IM |
Affiliation:
|
From the Department of Nuclear Medicine, Clínica Universidad de Navarra, Pamplona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Combination of 13N-Ammonia and 18F-FDG in Predicting Primary Central Nervous System Lymphomas in...
Next Document: Prevalence of stress reaction in the pars interarticularis in pediatric patients with new-onset lowe...