Document Detail

The Impact of Sodium and Potassium on Hypertension Risk.
MedLine Citation:
PMID:  25016398     Owner:  NLM     Status:  Publisher    
The pathogenic role of sodium surfeit in primary hypertension is widely recognized but that of potassium deficiency usually has been ignored or at best assigned subsidiary status. Weighing the available evidence, we recently proposed that the chief environmental factor in the pathogenesis of primary hypertension and the associated cardiovascular risk is the interaction of the sodium surfeit and potassium deficiency in the body. Here, we present the major evidence highlighting the relationship between high-sodium intake and hypertension. We then examine the blood pressure-lowering effects of potassium in conjunction with the pernicious impact of potassium deficiency on hypertension and cardiovascular risk. We conclude with summarizing recent human trials that have probed the joint effects of sodium and potassium intake on hypertension and its cardiovascular sequelae. The latter studies lend considerable fresh support to the thesis that the interaction of the sodium surfeit and potassium deficiency in the body, rather than either disturbance by itself, is the critical environmental factor in the pathogenesis of hypertension.
Horacio J Adrogué; Nicolaos E Madias
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Publication Detail:
Type:  REVIEW     Date:  2014-4-18
Journal Detail:
Title:  Seminars in nephrology     Volume:  34     ISSN:  1558-4488     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  257-272     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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