Document Detail


Impact of Short-Term Intake of Red Wine and Grape Polyphenols on Human Metabolome.
MedLine Citation:
PMID:  22372405     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolilc effects were determined in fasting plasma and 24-hour urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for four days in a placebo-controlled, cross-over study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hdyroxyphenylpropionic acid were confirmed as strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol-sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. Our results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.
Authors:
Doris M Jacobs; Jens C Fuhrmann; Ferdi A van Dorsten; Dietrich Rein; Sonja Peters; Ewoud J J van Velzen; Richard Draijer; John P M van Duynhoven; Ursula Garczarek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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