| Impact of serum apolipoprotein A-IV as a marker of cardiovascular disease in maintenance hemodialysis patients. | |
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MedLine Citation:
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PMID: 20609189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the relationship between serum apolipoprotein (apo) A-IV levels and markers for atherosclerosis, including carotid intima-media thickness (CIMT) and the ankle-brachial index (ABI), in hemodialysis patients. We performed a cross-sectional study involving 116 maintenance hemodialysis patients (70 males; median age, 64 years), measuring CIMT, ABI, the usual laboratory examinations, and serum apo A-IV before the dialysis session. The apo A-IV concentration was measured by a noncompetitive ELISA. Serum apo A-IV concentrations were significantly lower in hemodialysis patients with cardiovascular disease and plaque in the carotid artery. The apo A-IV level was positively associated with urea nitrogen and creatinine, and negatively associated with age, interleukin-6, the neutrophil/lymphocyte ratio, and maximum CIMT. Moreover, serum apo A-IV concentrations were significantly lower in the low ABI group. On logistic analysis, patients with high apo A-IV levels had a lower odds ratio for atherosclerosis (maximum CIMT > 1.0) and cardiovascular disease compared to patients with low apo A-IV levels. On stepwise multivariate regression analysis, the serum apo A-IV level was independently associated with creatinine, the neutrophil/lymphocyte ratio, and the maximum CIMT. Serum apo A-IV is associated with atherosclerotic lesions in hemodialysis patients. Apo A-IV levels may be useful for estimating the risk of cardiovascular disease in dialysis patients. |
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Authors:
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Maho Omori; Makoto Watanabe; Kei Matsumoto; Hirokazu Honda; Hiroaki Hattori; Tadao Akizawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 14 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 341-8 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Gyoutoku Sougou Hospital, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apolipoproteins A / blood* Atherosclerosis / diagnosis, etiology, physiopathology* Biological Markers / blood Cardiovascular Diseases / diagnosis, etiology, physiopathology* Carotid Arteries / metabolism Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Multivariate Analysis Regression Analysis Renal Dialysis* Risk Factors Tunica Intima / metabolism Tunica Media / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Biological Markers; 0/apolipoprotein A-IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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