Document Detail

Impact of serum apolipoprotein A-IV as a marker of cardiovascular disease in maintenance hemodialysis patients.
MedLine Citation:
PMID:  20609189     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the relationship between serum apolipoprotein (apo) A-IV levels and markers for atherosclerosis, including carotid intima-media thickness (CIMT) and the ankle-brachial index (ABI), in hemodialysis patients. We performed a cross-sectional study involving 116 maintenance hemodialysis patients (70 males; median age, 64 years), measuring CIMT, ABI, the usual laboratory examinations, and serum apo A-IV before the dialysis session. The apo A-IV concentration was measured by a noncompetitive ELISA. Serum apo A-IV concentrations were significantly lower in hemodialysis patients with cardiovascular disease and plaque in the carotid artery. The apo A-IV level was positively associated with urea nitrogen and creatinine, and negatively associated with age, interleukin-6, the neutrophil/lymphocyte ratio, and maximum CIMT. Moreover, serum apo A-IV concentrations were significantly lower in the low ABI group. On logistic analysis, patients with high apo A-IV levels had a lower odds ratio for atherosclerosis (maximum CIMT > 1.0) and cardiovascular disease compared to patients with low apo A-IV levels. On stepwise multivariate regression analysis, the serum apo A-IV level was independently associated with creatinine, the neutrophil/lymphocyte ratio, and the maximum CIMT. Serum apo A-IV is associated with atherosclerotic lesions in hemodialysis patients. Apo A-IV levels may be useful for estimating the risk of cardiovascular disease in dialysis patients.
Maho Omori; Makoto Watanabe; Kei Matsumoto; Hirokazu Honda; Hiroaki Hattori; Tadao Akizawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  14     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
Department of Nephrology, Gyoutoku Sougou Hospital, Chiba, Japan.
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MeSH Terms
Apolipoproteins A / blood*
Atherosclerosis / diagnosis,  etiology,  physiopathology*
Biological Markers / blood
Cardiovascular Diseases / diagnosis,  etiology,  physiopathology*
Carotid Arteries / metabolism
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Middle Aged
Multivariate Analysis
Regression Analysis
Renal Dialysis*
Risk Factors
Tunica Intima / metabolism
Tunica Media / metabolism
Reg. No./Substance:
0/Apolipoproteins A; 0/Biological Markers; 0/apolipoprotein A-IV

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