Document Detail

Impact of Salbutamol on Neuromuscular Function in Endurance Athletes.
MedLine Citation:
PMID:  23559124     Owner:  NLM     Status:  Publisher    
PURPOSE: The potential ergogenic effects of therapeutic inhaled salbutamol doses in endurance athletes have been controversially discussed for decades. We hypothesized that salbutamol inhalation may increase peripheral muscle contractility, reduce fatigability and improve force recovery following a localized exercise in endurance athletes. METHODS: Eleven healthy, non-asthmatics male athletes with high aerobic capacities were recruited to compare in a double-blinded crossover randomized study two dose levels of salbutamol (200 and 800 μg) and a placebo, administered by inhalation before a quadriceps fatigue test. Subjects performed an incremental exercise protocol consisting in sets of 10 intermittent isometric contractions starting at 20% of maximum voluntary contraction (MVC) with 10% MVC increment until exhaustion. Femoral nerve magnetic stimulation (FNMS) was used during and after MVC to evaluate neuromuscular fatigue after each set, at task failure, following 10 min and 30 min of recovery. RESULTS: Initial MVC and evoked muscular responses were not modified with salbutamol (p>0.05). The total number of submaximal contractions until task failure significantly differed between treatments (placebo 72 ± 7, 200 μg 78 ± 8 and 800 μg 82 ± 7; p<0.01). MVC and evoked muscular responses were similarly reduced with all treatments during the fatiguing task (all p>0.05). Voluntary activation was unaffected by the fatiguing task and treatments (p>0.05). CONCLUSION: Supra-therapeutic inhaled doses of β2-agonists increased quadriceps endurance during an incremental and localized fatiguing task in healthy endurance-trained athletes without significant effect on neuromuscular fatigue. Further studies are needed to clarify the underlying mechanisms.
Nicolas Decorte; Damien Bachasson; Michel Guinot; Patrice Flore; Patrick Levy; Samuel Verges; Bernard Wuyam
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-3
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Joseph Fourier University, HP2 Laboratory, F-38000, Grenoble, France 2 INSERM, U1042, F-38000, Grenoble, France 3 CHU Grenoble, Locomotion unit, Reeducation & Physiology, Clinical Physiology, Sleep and Exercise, F-38000, Grenoble, France 4 Institute for Doping Prevention, Grenoble, France.
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