| Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures. | |
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MedLine Citation:
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PMID: 22237861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the mechanical behavior of proximal pulmonary arteries (PAs) is crucial to evaluating pulmonary vascular function and right ventricular afterload. Early and current efforts focus on these arteries' histological changes, in vivo pressure-diameter behavior and mechanical properties under in vitro mechanical testing. However, the in vivo stretch and stress states remain poorly characterized. To further understand the mechanical behavior of the proximal PAs under physiological conditions, this study computed the residual stretch and the in vivo circumferential stretch state in the main pulmonary arteries in both control and hypertensive calves by using in vitro and in vivo artery geometry data, and modeled the impact of residual stretch and arterial remodeling on the in vivo circumferential stretch distribution and collagen engagement in the main pulmonary artery. We found that the in vivo circumferential stretch distribution in both groups was nonuniform across the vessel wall with the largest stretch at the outer wall, suggesting that collagen at the outer wall would engage first. It was also found that the circumferential stretch was more uniform in the hypertensive group, partially due to arterial remodeling that occurred during their hypoxic treatment, and that their onset of collagen engagement occurred at a higher pressure. It is concluded that the residual stretch and arterial remodeling have strong impact on the in vivo stretch state and the collagen engagement and thus the mechanical behavior of the main pulmonary artery in calves. |
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Authors:
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Lian Tian; Steven R Lammers; Philip H Kao; Joseph A Albietz; Kurt R Stenmark; H Jerry Qi; Robin Shandas; Kendall S Hunter |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-01-12 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 40 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-18 Completed Date: 2012-10-31 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1419-33 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA. ltian22@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Cattle Collagen / metabolism* Hypertension, Pulmonary* / metabolism, physiopathology Models, Cardiovascular* Pulmonary Artery* / metabolism, physiopathology Stress, Physiological* |
| Grant Support | |
ID/Acronym/Agency:
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K24 HL081506/HL/NHLBI NIH HHS; K24-HL081506/HL/NHLBI NIH HHS; K25 HL094749/HL/NHLBI NIH HHS; K25 HL094749-03/HL/NHLBI NIH HHS; K25-HL094749/HL/NHLBI NIH HHS; P50 HL084923/HL/NHLBI NIH HHS; SCCOR-HL084923/HL/NHLBI NIH HHS; T32 HL072738/HL/NHLBI NIH HHS; T32-HL072738/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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