Document Detail


Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures.
MedLine Citation:
PMID:  22237861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the mechanical behavior of proximal pulmonary arteries (PAs) is crucial to evaluating pulmonary vascular function and right ventricular afterload. Early and current efforts focus on these arteries' histological changes, in vivo pressure-diameter behavior and mechanical properties under in vitro mechanical testing. However, the in vivo stretch and stress states remain poorly characterized. To further understand the mechanical behavior of the proximal PAs under physiological conditions, this study computed the residual stretch and the in vivo circumferential stretch state in the main pulmonary arteries in both control and hypertensive calves by using in vitro and in vivo artery geometry data, and modeled the impact of residual stretch and arterial remodeling on the in vivo circumferential stretch distribution and collagen engagement in the main pulmonary artery. We found that the in vivo circumferential stretch distribution in both groups was nonuniform across the vessel wall with the largest stretch at the outer wall, suggesting that collagen at the outer wall would engage first. It was also found that the circumferential stretch was more uniform in the hypertensive group, partially due to arterial remodeling that occurred during their hypoxic treatment, and that their onset of collagen engagement occurred at a higher pressure. It is concluded that the residual stretch and arterial remodeling have strong impact on the in vivo stretch state and the collagen engagement and thus the mechanical behavior of the main pulmonary artery in calves.
Authors:
Lian Tian; Steven R Lammers; Philip H Kao; Joseph A Albietz; Kurt R Stenmark; H Jerry Qi; Robin Shandas; Kendall S Hunter
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-12
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  40     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-31     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1419-33     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA. ltian22@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Cattle
Collagen / metabolism*
Hypertension, Pulmonary* / metabolism,  physiopathology
Models, Cardiovascular*
Pulmonary Artery* / metabolism,  physiopathology
Stress, Physiological*
Grant Support
ID/Acronym/Agency:
K24 HL081506/HL/NHLBI NIH HHS; K24-HL081506/HL/NHLBI NIH HHS; K25 HL094749/HL/NHLBI NIH HHS; K25 HL094749-03/HL/NHLBI NIH HHS; K25-HL094749/HL/NHLBI NIH HHS; P50 HL084923/HL/NHLBI NIH HHS; SCCOR-HL084923/HL/NHLBI NIH HHS; T32 HL072738/HL/NHLBI NIH HHS; T32-HL072738/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9007-34-5/Collagen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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