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Impact of Repeated Endurance Runs on Cardiac Biomarkers and Function in Adolescents.
MedLine Citation:
PMID:  21502895     Owner:  NLM     Status:  Publisher    
PURPOSE:: This study examined the impact of two bouts of prolonged exercise performed on the same day on cardiac biomarkers and left ventricular (LV) function in trained adolescent runners. METHOD:: Twelve male adolescent runners (age 14.5 ±1.5 yr) performed two 45-min constant-load treadmill runs (RUN1 and RUN2), separated by 255 min of recovery, with intensity set at the running speeds that corresponded to ventilatory threshold (Thvent). Serum cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were assessed before (PRE1, PRE2), immediately after (POST1, POST2), and 255 min after each run (POST1+4, POST2+4) where PRE2 and POST1+4 were the same sample. LV function was examined echocardiographically before and after each run. RESULTS:: cTnT was undetectable at PRE1 and POST1 but was elevated in 8/12 (67%) runners POST1+4/PRE2 [median (range): 0.018 (<0.01-0.375]. cTnT decreased progressively thereafter up to POST2+4 (4/12, 33%). Data for NT-pro-BNP was significantly increased POST1 and POST2 but returned to baseline at POST1+4 and POST2+4. Ejection fraction (EF) was significantly reduced after RUN1 (74±5 to 70±5%, P<0.05), although still within normal range. There was no evidence of a cumulative drop in EF after RUN2 as the change was similar in magnitude (73±4% to 68±5%, P<0.05). The decrease in the early to atrial (E:A) diastolic flow velocity ratio was greater after RUN1 (1.91±0.13 to 1.83±0.08, P<0.05) than after RUN2 (1.86±0.15 to 1.85±0.12, P>0.05) and thus changes were not cumulative. CONCLUSION:: Neither cardiac biomarkers (cTnT or NT-pro-BNP) nor LV function (EF or E:A) demonstrate cumulative changes after two 45-min runs at Thvent separated by c.4 hours of recovery. Adolescent hearts seem to cope well with two prolonged runs performed on the same day.
Jinlei Nie; Keith P George; Tom K Tong; Ye Tian; Qingde Shi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-14
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China; 2Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK; 3Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China; 4China Institute of Sport Science, Beijing, China.
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