| Impact of Repeated Endurance Runs on Cardiac Biomarkers and Function in Adolescents. | |
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MedLine Citation:
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PMID: 21502895 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:: This study examined the impact of two bouts of prolonged exercise performed on the same day on cardiac biomarkers and left ventricular (LV) function in trained adolescent runners. METHOD:: Twelve male adolescent runners (age 14.5 ±1.5 yr) performed two 45-min constant-load treadmill runs (RUN1 and RUN2), separated by 255 min of recovery, with intensity set at the running speeds that corresponded to ventilatory threshold (Thvent). Serum cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were assessed before (PRE1, PRE2), immediately after (POST1, POST2), and 255 min after each run (POST1+4, POST2+4) where PRE2 and POST1+4 were the same sample. LV function was examined echocardiographically before and after each run. RESULTS:: cTnT was undetectable at PRE1 and POST1 but was elevated in 8/12 (67%) runners POST1+4/PRE2 [median (range): 0.018 (<0.01-0.375 ng.ml)]. cTnT decreased progressively thereafter up to POST2+4 (4/12, 33%). Data for NT-pro-BNP was significantly increased POST1 and POST2 but returned to baseline at POST1+4 and POST2+4. Ejection fraction (EF) was significantly reduced after RUN1 (74±5 to 70±5%, P<0.05), although still within normal range. There was no evidence of a cumulative drop in EF after RUN2 as the change was similar in magnitude (73±4% to 68±5%, P<0.05). The decrease in the early to atrial (E:A) diastolic flow velocity ratio was greater after RUN1 (1.91±0.13 to 1.83±0.08, P<0.05) than after RUN2 (1.86±0.15 to 1.85±0.12, P>0.05) and thus changes were not cumulative. CONCLUSION:: Neither cardiac biomarkers (cTnT or NT-pro-BNP) nor LV function (EF or E:A) demonstrate cumulative changes after two 45-min runs at Thvent separated by c.4 hours of recovery. Adolescent hearts seem to cope well with two prolonged runs performed on the same day. |
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Authors:
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Jinlei Nie; Keith P George; Tom K Tong; Ye Tian; Qingde Shi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-14 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China; 2Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK; 3Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China; 4China Institute of Sport Science, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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