Document Detail

Impact of pulsatile perfusion on clinical outcomes of neonates and infants with complex pathologies undergoing cardiopulmonary bypass procedures.
MedLine Citation:
PMID:  23145894     Owner:  NLM     Status:  MEDLINE    
The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n = 58) or the nonpulsatile perfusion group (Group NP, n = 31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P < 0.05) and had lower lactate levels (P < 0.001), higher urine output (P < 0.01), and higher albumin levels (P < 0.05). In addition, the pulsatile group had less ICU (P < 0.01) and hospital stays (P < 0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.
Tijen Alkan-Bozkaya; Atıf Akçevin; Halil Türkoğlu; Akif Ündar
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-11-12
Journal Detail:
Title:  Artificial organs     Volume:  37     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-08-02     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Copyright Information:
© 2012, Copyright the Authors. Artificial Organs © 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Department of Cardiovascular Surgery, Istanbul Medipol University, Istanbul, Turkey.
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MeSH Terms
Cardiac Surgical Procedures / methods*
Cardiopulmonary Bypass*
Chi-Square Distribution
Heart Defects, Congenital / surgery*
Infant, Newborn
Prospective Studies
Pulsatile Flow
Statistics, Nonparametric
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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