Document Detail

Impact of prenatal exposure to piperonyl butoxide and permethrin on 36-month neurodevelopment.
MedLine Citation:
PMID:  21300677     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent pesticide-monitoring results suggest that a shift in residential pesticide exposure from organophosphorus insecticides to pyrethroid insecticides has occurred. Pyrethroid insecticides are potential neurodevelopmental toxicants and have not been evaluated for developmental toxicity. Our objective was to explore the association between prenatal exposure to permethrin (a common pyrethroid) and piperonyl butoxide (a pyrethroid synergist) and 36-month neurodevelopment.
METHODS: Participants is this study were part of a prospective cohort of black and Dominican mothers and newborns living in low-income neighborhoods in New York City. We examined 36-month cognitive and motor development (using the Bayley Scales of Infant Development, second edition) as a function of permethrin levels measured in maternal and umbilical cord plasma collected on delivery and permethrin and piperonyl butoxide levels measured in personal air collected during pregnancy. All models were controlled for gender, gestational age, ethnicity, maternal education, maternal intelligence, quality of the home environment, and prenatal exposure to environmental tobacco smoke and chlorpyrifos.
RESULTS: Prenatal exposure to permethrin in personal air and/or plasma was not associated with performance scores for the Bayley Mental Developmental Index or the Psychomotor Developmental Index. After data adjustment, children more highly exposed to piperonyl butoxide in personal air samples (>4.34 ng/m(3)) scored 3.9 points lower on the Mental Developmental Index than those with lower exposures (95% confidence interval: -0.25 to -7.49).
CONCLUSIONS: Prenatal exposure to piperonyl butoxide was negatively associated with 36-month neurodevelopment.
Megan K Horton; Andrew Rundle; David E Camann; Dana Boyd Barr; Virginia A Rauh; Robin M Whyatt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-02-07
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-05-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e699-706     Citation Subset:  AIM; IM    
Sergievsky Center, New York, NY, USA.
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MeSH Terms
Child Development / drug effects*
Cognition / drug effects*
Developmental Disabilities / chemically induced*,  physiopathology
Follow-Up Studies
Infant, Newborn
Motor Activity / drug effects*
Nervous System / drug effects*,  growth & development
Pesticide Synergists / adverse effects
Piperonyl Butoxide / adverse effects*
Prenatal Exposure Delayed Effects*
Prospective Studies
Young Adult
Grant Support
Reg. No./Substance:
0/Pesticide Synergists; 51-03-6/Piperonyl Butoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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