| The impact of preexisting myocardial remodeling on ventricular function early after tetralogy of Fallot repair. | |
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MedLine Citation:
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PMID: 20650609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Twenty-three patients (median age 23 months) who underwent Fallot's tetralogy repair were investigated prospectively to detect a possible association between histopathologic myocardial remodeling and echocardiographic findings of systolic or diastolic ventricular dysfunction. METHODS: Intraoperatively resected infundibular bands and subendocardial biopsy samples from the right ventricle (RV) and left ventricle were obtained for histopathologic evaluation. Tissue Doppler echocardiographic interrogation of the ventricles was performed before surgery and in the postoperative period. RESULTS: Histopathologic data revealed hypertrophy of the RV cardiomyocytes and increased interstitial collagen in both ventricles. Mean values of RV isovolumic acceleration decreased significantly at the third evaluation compared with the preoperative values (P = .006). RV myocardial fibrosis greater than 8.3% was associated with a probability of altered E' of at least 0.7 (odds ratio = 2.31). CONCLUSION: Preoperative histologic myocardial remodeling influenced the postoperative RV function in this group of patients with late repair. Further studies are necessary to evaluate the myocardium in younger patients and to define its influence in the long-term follow-up. |
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Authors:
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Maria Cecília Knoll Farah; Cláudia Regina Pinheiro Castro; Valéria de Melo Moreira; Maria Angélica Binotto; Vitor Coimbra Guerra; Arlindo de Almeida Riso; Miguel Barbero Marcial; Antonio Augusto Lopes; Wilson Mathias; Vera Demarchi Aiello |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-21 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 23 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 912-8 Citation Subset: IM |
Copyright Information:
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2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Medical School, Health and Biological Sciences Center, University of Mato Grosso, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biopsy Child Child, Preschool Collagen / ultrastructure Echocardiography, Doppler* Electrocardiography Endothelium, Vascular / ultrastructure Female Humans Infant Logistic Models Male Myocytes, Cardiac / ultrastructure Prospective Studies Reproducibility of Results Statistics, Nonparametric Tetralogy of Fallot / physiopathology*, surgery, ultrasonography* Ventricular Dysfunction, Right / physiopathology*, surgery, ultrasonography* Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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