Document Detail


The impact of preexisting myocardial remodeling on ventricular function early after tetralogy of Fallot repair.
MedLine Citation:
PMID:  20650609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Twenty-three patients (median age 23 months) who underwent Fallot's tetralogy repair were investigated prospectively to detect a possible association between histopathologic myocardial remodeling and echocardiographic findings of systolic or diastolic ventricular dysfunction.
METHODS: Intraoperatively resected infundibular bands and subendocardial biopsy samples from the right ventricle (RV) and left ventricle were obtained for histopathologic evaluation. Tissue Doppler echocardiographic interrogation of the ventricles was performed before surgery and in the postoperative period.
RESULTS: Histopathologic data revealed hypertrophy of the RV cardiomyocytes and increased interstitial collagen in both ventricles. Mean values of RV isovolumic acceleration decreased significantly at the third evaluation compared with the preoperative values (P = .006). RV myocardial fibrosis greater than 8.3% was associated with a probability of altered E' of at least 0.7 (odds ratio = 2.31).
CONCLUSION: Preoperative histologic myocardial remodeling influenced the postoperative RV function in this group of patients with late repair. Further studies are necessary to evaluate the myocardium in younger patients and to define its influence in the long-term follow-up.
Authors:
Maria Cecília Knoll Farah; Cláudia Regina Pinheiro Castro; Valéria de Melo Moreira; Maria Angélica Binotto; Vitor Coimbra Guerra; Arlindo de Almeida Riso; Miguel Barbero Marcial; Antonio Augusto Lopes; Wilson Mathias; Vera Demarchi Aiello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-21
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  23     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  912-8     Citation Subset:  IM    
Copyright Information:
2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
Affiliation:
Medical School, Health and Biological Sciences Center, University of Mato Grosso, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biopsy
Child
Child, Preschool
Collagen / ultrastructure
Echocardiography, Doppler*
Electrocardiography
Endothelium, Vascular / ultrastructure
Female
Humans
Infant
Logistic Models
Male
Myocytes, Cardiac / ultrastructure
Prospective Studies
Reproducibility of Results
Statistics, Nonparametric
Tetralogy of Fallot / physiopathology*,  surgery,  ultrasonography*
Ventricular Dysfunction, Right / physiopathology*,  surgery,  ultrasonography*
Ventricular Remodeling*
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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