Document Detail

The Impact of Postnatal Antibiotics on the Preterm Intestinal Microbiome.
MedLine Citation:
PMID:  24819377     Owner:  NLM     Status:  Publisher    
Background:Development of the intestinal microbiome in preterm infants has significant impact on infant health. Our objective was to determine if duration of antibiotics within the first 10 and 30 days after birth affects the intestinal microbiome.Methods:Subjects were 24 0/7-31 6/7 weeks of gestational age who received =50% breast milk and a total of =100 ml/kg of feeds by 10d. Rectal (fecal) swabs were collected at 10d and 30d and analyzed by 16S rRNA pyrosequencing. At both time points, we examined the rectal microbiome from infants who received only 2 days of antibiotics and those who received at least 7 days of antibiotics.Results:In the 29 infants enrolled in our study, we found a decrease in diversity index (DI) from 10d samples in those who received more antibiotics. Such difference in diversity and richness was not as pronounced in 30d samples. Firmicutes and Bacteroidetes were most abundant in the 10d samples. While these two phyla remained dominant in 30d samples, there was an increase in Proteobacteria and Actinobacteria.Conclusions:Despite antibiotic therapy, neonates continue to acquire bacteria in the GI tract. The process of bacterial acquisition is perturbed with the use of antibiotics.Pediatric Research (2014); doi:10.1038/pr.2014.69.
Majd Dardas; Steven R Gill; Alex Grier; Gloria S Pryhuber; Ann L Gill; Yi-Horng Lee; Ronnie Guillet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-12
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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