| The Impact of Population-Based Screening Studies on Hemochromatosis Screening Practices. | |
| | |
MedLine Citation:
|
PMID: 22160492 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: To determine if community population screening studies for hemochromatosis affected HFE genetic screening practices in non-study populations. METHODS: An audit of all genetic testing for HFE mutations at London Health Sciences Center, London, Ontario, Canada from 1997 to 2010 was performed. The frequency of genetic testing and the frequency of C282Y homozygous cases identified during the years of the London Red Cross (1998-1999) and HEIRS (2000-2005) screening studies were compared with the corresponding frequencies in the specified years outside this range (1997-1998 and 2006-2010). RESULTS: An increase in HFE gene mutation testing is seen during the London Red Cross study, and the frequency of testing rose further during the HEIRS study. Genetic screening activity continued to increase in the years after publication of the HEIRS study. The proportion of patients with homozygosity for C282Y mutation remained relatively constant despite fluctuations in numbers of persons screened per annum. CONCLUSIONS: The rise in HFE gene testing among non-study populations during the HH studies could be explained by the Hawthorne effect, a phenomenon referring to the improvement or modification of behavior by a population as a consequence of it being studied. In this case, we postulate that primary care physicians at our center performed more HFE gene tests for their patients as a consequence of being affected by knowledge of the screening studies. Despite a general increase in testing during and after completion of the studies, the total number of hemochromatosis cases (C282Y homozygotes) diagnosed per annum remained relatively constant. |
| | |
Authors:
|
Natasha Chandok; Mark Speechley; Peter J Ainsworth; Subrata Chakrabarti; Paul C Adams |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-10 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: - ISSN: 1573-2568 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medicine, University Hospital, University of Western Ontario, 339 Windermere Rd, London, ON, N6A 5A5, Canada, chandok.n@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple brain abscess from dental origin: case report and literature review.
Next Document: PSS-3D1D: an improved 3D1D profile method of protein fold recognition for the annotation of twilight...