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Impact of Peripherally Established Cardiopulmonary Bypass on Regional and Systemic Blood Lactate Levels.
MedLine Citation:
PMID:  22129493     Owner:  NLM     Status:  Publisher    
BACKGROUND: To investigate blood lactate levels during and after peripherally established cardiopulmonary bypass (CPB). METHODS: In 86 patients (41 males, mean age 13.8±7.2), CPB was established via femoral vein and artery cannulation for thoracoscopic closure of atrial (n=54) or ventricular septal defect (n=32). Arterial and venous blood lactate levels were measured from the cannulated limb during CPB, and from systemic circulation after CPB. RESULTS: The mean duration of CPB and cannulation of a lower extremity were 50.0±10.5min and 76.0±18.5min, respectively. The mean arterial lactate level measured from the systemic circulation remained unchanged during CPB (P>0.05). In patients with CPB for 3h or more, mean arterial lactate in the cannulated limb were higher than the baseline values (3.3±0.5 vs 0.8±0.2mmol/L, P<0.05). In patients with more than 2h of CPB, mean venous lactate levels in the cannulated limb were also higher than the baseline values (3.4±0.2 vs 1.1±0.3mmol/L, P<0.05). Within 6h after CPB, systemic arterial (3.0±0.2 vs 0.8±0.1mmol/L, P<0.01) and venous lactate levels (6.5±0.2 vs 1.0±0.1mmol/L, P<0.01) were higher than the pre-CPB values. CONCLUSIONS: Peripherally established CPB was associated with an arterial and venous lactate elevation in local and systemic circulation. The duration of CPB and lower limb cannulation appears to be related to the lactate elevation.
Ming-Feng Dong; Zeng-Shan Ma; Jian-Tang Wang; Shou-Dong Chai; Pei-Zhe Tang; Le-Xin Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-28
Journal Detail:
Title:  Heart, lung & circulation     Volume:  -     ISSN:  1444-2892     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.
Department of Cardiac Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, PR China.
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