Document Detail

Impact of Ovabloc intratubal polymer on the morphology of the fallopian tube.
MedLine Citation:
PMID:  8601529     Owner:  NLM     Status:  MEDLINE    
Treatment of the fallopian tubes by Ovabloc silicone intratubal polymer (ITP; Dow Corning silastic 382 Medical-Grade Elastomer) is used for permanent female contraception. Studies on animals show minor structural changes in the tubal epithelial lining caused by the ITP and suggest reversibility of tubal integrity after removal of the polymer. The aim of this study was to examine the impact of the ITP on the human tubal epithelial lining. From 13 patients treated with ITP, 23 fallopian tubes were studied by light microscopy and transmission electron microscopy. The examined 19 isthmical and 10 ampullary parts show marked structural changes. In the isthmical parts of the fallopian tubes, cellular and ciliary changes develop immediately after insertion of the silicone polymer. As for the ampullary parts, the cellular and ciliary changes are related to the ITP exposure time. The changes in the isthmus and ampulla are persistent for at least 15 months after removal of the ITP. It is not known whether the effects are reversible.
G van der Leij; C van Krimpen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  14     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1996-05-07     Completed Date:  1996-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
Department of Gynaecology and Obstetrics, Schieland Hospital, The Netherlands.
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MeSH Terms
Cilia / drug effects
Fallopian Tubes / drug effects*,  ultrastructure
Microscopy, Electron
Retrospective Studies
Silicone Elastomers / pharmacology*
Sterilization, Tubal / methods*
Reg. No./Substance:
0/Ovabloc; 0/Silicone Elastomers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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