Document Detail

The impact of obstructive sleep apnea on chronic kidney disease.
MedLine Citation:
PMID:  20676805     Owner:  NLM     Status:  MEDLINE    
Obstructive sleep apnea (OSA) is an important clinical problem in the chronic kidney disease (CKD) population. OSA is associated with hypoxemia and sleep fragmentation, which activates the sympathetic nervous system, the renin-angiotensin-aldosterone system, alters cardiovascular hemodynamics, and results in free radical generation. In turn, a variety of deleterious processes such as endothelial dysfunction, inflammation, platelet aggregation, atherosclerosis, and fibrosis are triggered, predisposing individuals to adverse cardiovascular events and likely renal damage. Independent of obesity, OSA is associated with glomerular hyperfiltration and may be an independent predictor of proteinuria, a risk factor for CKD progression. OSA is also associated with hypertension, another important risk factor for CKD progression, particularly proteinuric CKD. OSA may mediate renal damage via several mechanisms, and there is a need to better elucidate the impact of OSA on incident renal disease and CKD progression.
Gbemisola A Adeseun; Sylvia E Rosas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  12     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-02-03     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  378-83     Citation Subset:  IM    
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MeSH Terms
Anoxia / etiology
Atherosclerosis / epidemiology*,  pathology
Cross-Sectional Studies
Diabetes Mellitus / epidemiology*
Disease Progression
Endothelium, Vascular / pathology
Hemodynamics / physiology
Hypertension / complications,  epidemiology*,  physiopathology,  therapy
Kidney Function Tests
Obesity / epidemiology*
Proteinuria / etiology
Renal Insufficiency, Chronic / diagnosis,  epidemiology*,  etiology,  physiopathology,  therapy
Renin-Angiotensin System / physiology
Risk Factors
Sleep Apnea, Obstructive / complications,  epidemiology*,  metabolism,  physiopathology,  therapy
Sleep Deprivation / etiology
Sympathetic Nervous System / physiology
Treatment Outcome
Grant Support
5R01D080033-02//PHS HHS; R01 DK 80033/DK/NIDDK NIH HHS; R01 DK080033/DK/NIDDK NIH HHS; R21 HL 86971/HL/NHLBI NIH HHS

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