| The impact of obesity on urinary incontinence symptoms, severity, urodynamic characteristics and quality of life. | |
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MedLine Citation:
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PMID: 20018326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We compared urinary incontinence severity measures and the impact of stress urinary incontinence in normal, overweight and obese women. MATERIALS AND METHODS: Baseline characteristics of subjects in the SISTEr (655) and the TOMUS (597) were analyzed. Body mass index was defined as normal (less than 25 kg/m(2)), overweight (25 to less than 30 kg/m(2)) and obese (30 kg/m(2) or greater). Independent urinary incontinence severity measures included a 3-day diary including incontinence episode frequency, Urogenital Distress Inventory scores and Valsalva leak point pressure from urodynamic testing. Impact was measured using the Incontinence Impact Questionnaire. Multivariable regression models were fit for each severity measure (Urogenital Distress Inventory, incontinence episode frequency, Valsalva leak point pressure and Incontinence Impact Questionnaire) on weight category. Covariates included age, race, diabetes and variables significantly associated with body mass index on bivariate analysis. RESULTS: Mean age (SD) of participants was 51.9 (10.3) in SISTEr and 52.9 (11.0) in TOMUS. In each trial 45% of subjects were obese. In SISTEr multivariable regression analyses showed that higher weight category was independently associated with higher mean Urogenital Distress Inventory score (p = 0.003), incontinence episode frequency (p <0.0001), Valsalva leak point pressure (p = 0.003) and Incontinence Impact Questionnaire score (p = 0.0004). In TOMUS higher weight category was not associated with Urogenital Distress Inventory score (p = 0.24) but was associated with higher incontinence episode frequency (p = 0.0003), Valsalva leak point pressure (p = 0.0006) and Incontinence Impact Questionnaire score (p <0.0001). CONCLUSIONS: Obese women undergoing surgery for stress urinary incontinence report more incontinence episodes, more symptom distress and worse quality of life despite better measure of urethral function (higher Valsalva leak point pressure) on urodynamics. |
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Authors:
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Holly E Richter; Kimberly Kenton; Liyuan Huang; Ingrid Nygaard; Stephen Kraus; Emily Whitcomb; Toby C Chai; Gary Lemack; Larry Sirls; Kimberly J Dandreo; Anne Stoddard |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2009-12-16 |
Journal Detail:
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Title: The Journal of urology Volume: 183 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-02-23 Revised Date: 2012-03-26 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 622-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 American Urological Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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University of Alabama at Birmingham, Birmingham, Alabama, USA. hrichter@uabmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Middle Aged Obesity / complications* Overweight / complications* Quality of Life* Severity of Illness Index Urinary Incontinence / etiology*, physiopathology* Urodynamics* |
| Grant Support | |
ID/Acronym/Agency:
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U01 DK060380-07/DK/NIDDK NIH HHS; U01 DK58225/DK/NIDDK NIH HHS; U01 DK58229/DK/NIDDK NIH HHS; U01 DK58231/DK/NIDDK NIH HHS; U01 DK58234/DK/NIDDK NIH HHS; U01 DK60379/DK/NIDDK NIH HHS; U01 DK60380/DK/NIDDK NIH HHS; U01 DK60393/DK/NIDDK NIH HHS; U01 DK60395/DK/NIDDK NIH HHS; U01 DK60397/DK/NIDDK NIH HHS; U01 DK60401/DK/NIDDK NIH HHS |
| Comments/Corrections | |
Comment In:
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J Urol. 2010 Feb;183(2):427-9
[PMID:
20006860
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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