| Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects. | |
| | |
MedLine Citation:
|
PMID: 11875321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the acute effects of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects. METHODS: Changes of renal plasma flow (RPF) and glomerular filtration rate (GFR) in response to intravenous infusions of NG-monomethyl-l-arginine (l-NMMA) (3 mg/kg per 30 min) were measured in 32 normotensive and in 39 essential hypertensive patients by use of clearance technique. RESULTS: l-NMMA significantly decreased RPF in normotensive and hypertensive individuals (P < 0.001), while GFR was preserved. Changes of renal hemodynamic parameters were similar in hypertensive and normotensive subjects (deltaRPF: -88 +/- 89 versus -81 +/- 105 ml/min, P = NS; deltaGFR 1.6 +/- 8.2 versus 4.3 +/- 8.9 ml/min, P = NS) Furthermore, l-NMMA increased mean arterial pressure (deltaMAP 5.3 +/- 6.3 versus 6.0 +/- 6.1 mmHg, P = NS) and decreased heart rate (deltaHR -5.8 +/- 3.9 versus -4.1 +/- 3.8 beats/min, P = NS) to a similar extent in both groups. CONCLUSION: Basal NO synthesis of the renal vasculature is not impaired in patients with established essential hypertension. |
| | |
Authors:
|
Johannes Jacobi; Markus P Schneider; Stefan John; Roland E Schmieder |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension Volume: 20 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-03-04 Completed Date: 2002-06-20 Revised Date: 2010-03-23 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 525-30 Citation Subset: IM |
Affiliation:
|
Department of Medicine/Nephrology, University of Erlangen-N?rnberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / drug effects Cohort Studies Enzyme Inhibitors / administration & dosage, pharmacology* Female Heart Rate / drug effects Hemodynamics / drug effects Humans Hypertension / physiopathology* Injections, Intravenous Male Middle Aged Nitric Oxide Synthase / antagonists & inhibitors* Reference Values Renal Circulation / drug effects* omega-N-Methylarginine / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 17035-90-4/omega-N-Methylarginine; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
Comment In:
|
J Hypertens. 2002 Mar;20(3):391-3
[PMID:
11875304
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Silent cerebral white matter lesions in middle-aged essential hypertensive patients.
Next Document: Relations of pulse pressure and other components of blood pressure to preclinical echocardiographic ...