Document Detail

Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects.
MedLine Citation:
PMID:  11875321     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the acute effects of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects. METHODS: Changes of renal plasma flow (RPF) and glomerular filtration rate (GFR) in response to intravenous infusions of NG-monomethyl-l-arginine (l-NMMA) (3 mg/kg per 30 min) were measured in 32 normotensive and in 39 essential hypertensive patients by use of clearance technique. RESULTS: l-NMMA significantly decreased RPF in normotensive and hypertensive individuals (P < 0.001), while GFR was preserved. Changes of renal hemodynamic parameters were similar in hypertensive and normotensive subjects (deltaRPF: -88 +/- 89 versus -81 +/- 105 ml/min, P = NS; deltaGFR 1.6 +/- 8.2 versus 4.3 +/- 8.9 ml/min, P = NS) Furthermore, l-NMMA increased mean arterial pressure (deltaMAP 5.3 +/- 6.3 versus 6.0 +/- 6.1 mmHg, P = NS) and decreased heart rate (deltaHR -5.8 +/- 3.9 versus -4.1 +/- 3.8 beats/min, P = NS) to a similar extent in both groups. CONCLUSION: Basal NO synthesis of the renal vasculature is not impaired in patients with established essential hypertension.
Johannes Jacobi; Markus P Schneider; Stefan John; Roland E Schmieder
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  20     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-04     Completed Date:  2002-06-20     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  525-30     Citation Subset:  IM    
Department of Medicine/Nephrology, University of Erlangen-N?rnberg, Germany.
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MeSH Terms
Blood Pressure / drug effects
Cohort Studies
Enzyme Inhibitors / administration & dosage,  pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects
Hypertension / physiopathology*
Injections, Intravenous
Middle Aged
Nitric Oxide Synthase / antagonists & inhibitors*
Reference Values
Renal Circulation / drug effects*
omega-N-Methylarginine / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Enzyme Inhibitors; 17035-90-4/omega-N-Methylarginine; EC Oxide Synthase
Comment In:
J Hypertens. 2002 Mar;20(3):391-3   [PMID:  11875304 ]

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