| Impact of myocardial acceleration during isovolumic contraction in evaluating subclinical right ventricular systolic dysfunction in type 2 diabetes mellitus patients. | |
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MedLine Citation:
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PMID: 20584066 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: In diabetes mellitus (DM) patients, left ventricular dysfunction is widely evaluated and established by conventional diagnostic methods, whereas right ventricular (RV) function is not as sufficiently evaluated. The aim of this study is to assess the preclinical effects of DM on RV function by using novel Tissue Doppler Imaging (TDI)-derived indices. METHODS: The study included 96 patients with type II DM [60 with DM only and 36 patients with coexisting DM and hypertension (DMHT)] and 40 healthy controls. Conventional parameters and TDI-derived systolic velocities of tricuspid annulus [isovolumic myocardial acceleration (IVA), peak myocardial velocity during isovolumic contraction (IVV), peak systolic velocity during ejection period (Sa), RV Tei index] were measured. RESULTS: TDI-derived RV IVA was significantly lower in both DM and DMHT patients compared to controls indicating subclinical impairment in RV systolic function in the study patients (P = 0,0001). However RV IVA was similar in DM and DMHT subgroup supporting RV systolic impairment in DM was independent from HT. In correlation analysis, RV IVA was significantly correlated with the existence of diabetic nephropathy (r =-0,38; P = 0,003), retinopathy (r =-0,35; P = 0,006), insulin resistance (r =-0,52; P = 0,0001). CONCLUSIONS: Diabetes is associated with subclinical RV systolic dysfunction, regardless of coexisting hypertension. Tissue Doppler-derived IVA; is a novel, non-invasive parameter which may be used in early detection of RV systolic dysfunction in patients with DM. |
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Authors:
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Yelda Tayyareci; Selen Yurdakul; Gulsah Tayyareci; Yilmaz Nisanci; Berrin Umman; Zehra Buğra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 27 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 1211-8 Citation Subset: IM |
Copyright Information:
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© 2010, Wiley Periodicals, Inc. |
Affiliation:
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Cardiology Division, Florence Nightingale Hospital, Istanbul, Turkey. yeldatayyareci@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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