| Impact of multiple and long sirolimus-eluting stent implantation on 3-year clinical outcomes in the j-Cypher Registry. | |
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MedLine Citation:
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PMID: 20170875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Our aim was to study the relationships between total stent length (TSL) and long-term clinical outcomes after sirolimus-eluting stent (SES) implantation. BACKGROUND: SES compared with bare-metal stent use for long lesion treatment is associated with reduced restenosis rates. METHODS: Three-year follow-up data were available for 10,773 patients (14,651 lesions) that had been treated with only SES (Cypher, Cordis Corp., Warren, New Jersey) in the j-Cypher registry. Patients and lesions were divided into quartile groups: TSL per patient (Q1: 8 to 23 mm, Q2: 24 to 36 mm, Q3: 37 to 54 mm, Q4: 55 to 293 mm), and TSL per lesion (QA: 8 to 18 mm, QB: 19 to 23 mm, QC: 24 to 33 mm, QD: 34 to 150 mm). RESULTS: In per-lesion data, longer TSL increased target lesion revascularization (TLR) rates but did not increase stent thrombosis rates (p = 0.2324). In per-patient data, the incidences of TLR remarkably increased with increasing TSL. Incidence of composite of death and myocardial infarction also increased with increasing TSL; however, after adjustment for baseline differences, there was no statistical significance. Definite stent thrombosis rate in group Q4 was significantly higher than in other groups, both unadjusted (hazard ratio: 1.770, p = 0.0081) and adjusted (hazard ratio: 1.727, p = 0.0122) for baseline differences. CONCLUSIONS: TSL per lesion and patient had significantly impacts on TLR rates. Longer TSL per patient was associated with increased incidence of stent thrombosis through 3 years. |
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Authors:
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Shinichi Shirai; Takeshi Kimura; Masakiyo Nobuyoshi; Takeshi Morimoto; Kenji Ando; Yoshimitsu Soga; Kyohei Yamaji; Katsuhiro Kondo; Koyu Sakai; Takeshi Arita; Masahiko Goya; Masashi Iwabuchi; Hiroyoshi Yokoi; Hideyuki Nosaka; Kazuaki Mitsudo; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: JACC. Cardiovascular interventions Volume: 3 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2011-06-02 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 180-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiology, Kokura Memorial Hospital, Kokura, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Confidence Intervals Coronary Artery Disease / mortality, prevention & control Coronary Restenosis / mortality, prevention & control* Drug-Eluting Stents* Female Humans Immunosuppressive Agents / therapeutic use* Japan Logistic Models Male Proportional Hazards Models Registries Risk Risk Factors Sirolimus / therapeutic use* Time Factors Treatment Outcome* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 53123-88-9/Sirolimus |
| Comments/Corrections | |
Comment In:
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JACC Cardiovasc Interv. 2010 Feb;3(2):189-90
[PMID:
20170876
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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