Document Detail

Impact of MicroRNA in Normal and Pathological Respiratory Epithelia.
MedLine Citation:
PMID:  21594785     Owner:  NLM     Status:  In-Data-Review    
Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general experimental strategy to identify specific miRNA expression profiles and to highlight the functional networks operating between them and their mRNA targets, including several miRNAs deregulated in cystic fibrosis and during differentiation of airway epithelial cells.
Lisa Giovannini-Chami; Nathalie Grandvaux; Laure-Emmanuelle Zaragosi; Karine Robbe-Sermesant; Brice Marcet; Bruno Cardinaud; Christelle Coraux; Yves Berthiaume; Rainer Waldmann; Bernard Mari; Pascal Barbry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  741     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-91     Citation Subset:  IM    
CNRS, Université de Nice Sophia Antipolis, IPMC, UMR6097, Sophia Antipolis, France,
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