Document Detail


Impact of Metabolic Syndrome on Various Aspects of Microcirculation and Major Adverse Cardiac Events in Patients With ST-Segment Elevation Myocardial Infarction.
MedLine Citation:
PMID:  22664935     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Microvascular impairment is associated with a poor prognosis even after successful percutaneous coronary intervention (PCI) in acute myocardial infarction. The aim of the present study was to examine the impact of metabolic syndrome (MetS) on various aspects of microvascular function and clinical outcomes. Methods and Results: In 216 consecutive patients with ST-segment elevation myocardial infarction (STEMI) after successful primary PCI, data were collected and analyzed on epicardial coronary flow, ST-segment resolution (STR) on electrocardiography, maximum serum creatine kinase levels, and the incidence of major adverse cardiac events (MACE). The prevalence of MetS was 40.7% (88 patients). Corrected Thrombolysis In Myocardial Infarction frame count was significantly higher in the MetS group than in the non-MetS group (28.1±9.4 vs. 24.7±7.9, P=0.04). STR ≥50% was observed in 51.1% and 69.5%, respectively (P=0.01). Patients with MetS also had higher maximum creatine kinase levels (3,470±2,320IU/L vs. 2,664±1,850IU/L, P=0.01). On logistic regression analysis after adjustment for confounders, MetS was an independent negative predictor of complete STR (odds ratio, 0.49; 95% confidence interval [CI]: 0.25-0.95, P=0.03). On Cox multivariate analysis, MetS was an independent predictor for MACE (hazard ratio, 4.85; 95% CI: 1.28-18.3, P=0.02). Conclusions: MetS may damage microcirculation after direct PCI in patients with STEMI and lead to poor prognosis.
Authors:
Yasuhiro Uchida; Satoshi Ichimiya; Hideki Ishii; Masaaki Kanashiro; Junji Watanabe; Daiji Yoshikawa; Kyosuke Takeshita; Shinichi Sakai; Tetsuya Amano; Tatsuaki Matsubara; Toyoaki Murohara
Related Documents :
10929745 - Myocardial ischemia caused by an hydatid cyst of the interventricular septum successful...
8526695 - Evaluation of the patient with 'rule out myocardial infarction'.
9110195 - Is 'diaphragmatic' attenuation a misnomer?. evaluation of the anatomic cause of 'diaphr...
23393945 - Early surgical repair of an acute post-infarction left ventricular pseudoaneurysm compl...
18430815 - Cardiac valve disease: spectrum of findings on cardiac 64-mdct.
17870005 - Outcomes of mitral valve repair for mitral regurgitation due to degenerative disease.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Nagoya University Graduate School of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of tear protein levels in breast cancer patients and healthy controls using a...
Next Document:  Novel Risk Scoring System With Preoperative Objective Parameters Gives a Good Prediction of 1-Year M...