Document Detail


Impact of the metabolic syndrome on the clinical outcome of patients with acute ST-elevation myocardial infarction.
MedLine Citation:
PMID:  20890426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8±12.3 yr); group II: Non-MS (n=808, 675 men, 64.2±13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (P=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (P=0.01). The incidence of in-hospital death was higher in group I than in group II (P=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.
Authors:
Min Goo Lee; Myung Ho Jeong; Youngkeun Ahn; Shung Chull Chae; Seung Ho Hur; Taek Jong Hong; Young Jo Kim; In Whan Seong; Jei Keon Chae; Jay Young Rhew; In Ho Chae; Myeong Chan Cho; Jang Ho Bae; Seung Woon Rha; Chong Jin Kim; Donghoon Choi; Yang Soo Jang; Junghan Yoon; Wook Sung Chung; Jeong Gwan Cho; Ki Bae Seung; Seung Jung Park
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Publication Detail:
Type:  Journal Article     Date:  2010-09-17
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-02-17     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1456-61     Citation Subset:  IM    
Affiliation:
The Heart Center of Chonnam National University Hospital, Gwangju, Korea.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Age Factors
Aged
C-Reactive Protein / analysis
Cholesterol, LDL / blood
Coronary Angiography
Female
Humans
Male
Metabolic Syndrome X / complications*,  epidemiology
Middle Aged
Multivariate Analysis
Myocardial Infarction / complications*,  mortality,  therapy
Predictive Value of Tests
Prognosis
Treatment Outcome
Ventricular Dysfunction, Left / complications,  physiopathology
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; 9007-41-4/C-Reactive Protein
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