Document Detail

The Impact of Malaria in Pregnancy on Changes in Blood Pressure in Children During Their First Year of Life.
MedLine Citation:
PMID:  24126169     Owner:  NLM     Status:  Publisher    
We established a maternal birth cohort in Ibadan, Nigeria, where malaria is hyperendemic, to assess how intrauterine exposure to malaria affected infant blood pressure (BP) development. In a local maternity hospital, healthy pregnant women had regular blood films for malaria parasites from booking to delivery. Growth and BP were measured on 318 babies, all followed from birth to 3 and 12 months. Main outcomes were standardized measures of anthropometry and change in BP to 1 year. Babies exposed to maternal malaria were globally smaller at birth, and boys remained smaller at 3 months and 1 year. Change in systolic BP (SBP) during the year was greater in boys than in girls (20.9 versus 15.7 mm Hg; P=0.002) but greater in girls exposed to maternal malaria (18.7 versus 12.7 mm Hg; 95% confidence interval, 1-11 mm Hg; P=0.02). Eleven percent of boys (greater than twice than expected) had a SBP ≥95th percentile (hypertensive, US criteria), of whom 68% had maternal malaria exposure. On regression analysis (β coefficients, mm Hg), sex (boys>girls; β=4.4; 95% confidence interval, 1.1-7.7; P=0.01), maternal malaria exposure (3.64; 0.3-6.9; P=0.03), and weight change (2.4; 0.98-3.8/1 standard deviation score; P=0.001) all independently increased SBP change to 1 year, whereas increase in length decreased SBP (-1.98; -3.6 to -0.40). In conclusion, malaria-exposed boys had excess hypertension, whereas malaria-exposed girls a greater increase in SBP. Intrauterine exposure to malaria had sex-dependent effects on BP, independent of infant growth. Because infant-child-adult BP tracking is powerful, a malarial effect may contribute to the African burden of hypertension.
Omolola O Ayoola; Olayemi O Omotade; Isla Gemmell; Peter E Clayton; J Kennedy Cruickshank
Related Documents :
23292629 - Transcutaneous bilirubin measurement in preterm neonates.
12806889 - Evaluation of a forced-air-ventilated micro-isolation system for protection of mice aga...
11416879 - Patient-ventilator interactions in new modes of patient-triggered ventilation.
23543239 - Maternal and neonatal outcome in triplet, quadruplet and quintuplet gestations followin...
23467949 - Adiponectin and visfatin levels in extremely low birth weight infants; they are also at...
12548379 - Prolonged ventilation and intact survival in very low birth weight infants.
1794889 - A controlled study of sugar-fortified milk feeding for prevention of neonatal hypoglyca...
7820709 - Computerised determination of spontaneous inspiratory and expiratory times in premature...
3327939 - Surfactant substitution in the newborn by application of artificial surfactant.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-14
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiovascular Sciences and Paediatric Endocrinology Groups, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association of Alcohol Consumption With Incident Hypertension Among Middle-Aged and Older Japanese P...
Next Document:  Williams Syndrome Predisposes to Vascular Stiffness Modified by Antihypertensive Use and Copy Number...