Document Detail


The impact of macular edema on visual function in intermediate, posterior, and panuveitis.
MedLine Citation:
PMID:  22530874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the impact of macular edema on visual acuity and visual field sensitivity in uveitis.
DESIGN: This study utilized baseline data from the Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized, parallel treatment clinical trial comparing alternative treatments for intermediate, posterior and panuveitis.
PATIENTS & METHODS: 255 patients (481 eyes with uveitis) recruited at 23 subspecialty centers. Visual acuity, optical coherence tomography and Humphrey 24-2 visual field testing.
RESULTS: Macular edema was associated with impaired visual acuity (p < 0.01). Different phenotypes of macular edema were associated with different degrees of visual impairment: cystoid changes without retinal thickening were associated with moderately impaired visual acuity (-5 ETDRS letters), but visual acuity was worse in eyes with retinal thickening (-13 letters) and with both cysts and thickening (-19 letters). Uveitis sufficient to satisfy the study's inclusion criteria was associated with impaired visual field sensitivity, but eyes with macular edema had even worse visual field sensitivity (p < 0.01).
CONCLUSIONS: The observation that macular edema substantially reduces visual function suggests macular edema itself is an important endpoint to study in the treatment of uveitis. As uveitis and macular edema both impair visual field sensitivity as measured by Humphrey 24-2 perimetry, both should be considered when evaluating patients with uveitis and raised intraocular pressure for glaucoma.
Authors:
Simon R J Taylor; Susan L Lightman; Elizabeth A Sugar; Glen J Jaffe; William R Freeman; Michael M Altaweel; Igor Kozak; Janet T Holbrook; Douglas A Jabs; John H Kempen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-24
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  20     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-03     Completed Date:  2012-09-14     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-81     Citation Subset:  IM    
Affiliation:
Division of Immunology & Inflammation, Faculty of Medicine, Imperial College London, London, UK. s.r.taylor@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fluorescein Angiography
Glaucoma / diagnosis
Humans
Macular Edema / complications*,  diagnosis,  physiopathology
Male
Middle Aged
Multicenter Studies as Topic
Panuveitis / etiology*,  physiopathology
Randomized Controlled Trials as Topic
Tomography, Optical Coherence
Uveitis, Intermediate / etiology*,  physiopathology
Visual Acuity / physiology*
Visual Fields / physiology
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
U10 EY 014655/EY/NEI NIH HHS; U10 EY 014656/EY/NEI NIH HHS; U10 EY 014660/EY/NEI NIH HHS; U10 EY014655/EY/NEI NIH HHS
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