Document Detail

The impact of macular edema on visual function in intermediate, posterior, and panuveitis.
MedLine Citation:
PMID:  22530874     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the impact of macular edema on visual acuity and visual field sensitivity in uveitis.
DESIGN: This study utilized baseline data from the Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized, parallel treatment clinical trial comparing alternative treatments for intermediate, posterior and panuveitis.
PATIENTS & METHODS: 255 patients (481 eyes with uveitis) recruited at 23 subspecialty centers. Visual acuity, optical coherence tomography and Humphrey 24-2 visual field testing.
RESULTS: Macular edema was associated with impaired visual acuity (p < 0.01). Different phenotypes of macular edema were associated with different degrees of visual impairment: cystoid changes without retinal thickening were associated with moderately impaired visual acuity (-5 ETDRS letters), but visual acuity was worse in eyes with retinal thickening (-13 letters) and with both cysts and thickening (-19 letters). Uveitis sufficient to satisfy the study's inclusion criteria was associated with impaired visual field sensitivity, but eyes with macular edema had even worse visual field sensitivity (p < 0.01).
CONCLUSIONS: The observation that macular edema substantially reduces visual function suggests macular edema itself is an important endpoint to study in the treatment of uveitis. As uveitis and macular edema both impair visual field sensitivity as measured by Humphrey 24-2 perimetry, both should be considered when evaluating patients with uveitis and raised intraocular pressure for glaucoma.
Simon R J Taylor; Susan L Lightman; Elizabeth A Sugar; Glen J Jaffe; William R Freeman; Michael M Altaweel; Igor Kozak; Janet T Holbrook; Douglas A Jabs; John H Kempen
Related Documents :
22630094 - Intravitreal bevacizumab in central serous chorioretinopathy.
22426754 - Surgical management of lacrimal punctal cauterization in chronic gvhd-related dry eye w...
15988924 - Effect of experimental scleral shortening on axial length of the rabbit eye.
20363504 - Corneal shape changes after 2.0-mm or 3.0-mm clear corneal versus scleral tunnel incisi...
17573114 - The influence of corneal properties on rebound tonometry.
7928114 - Decoupling motor memory strategies: effects of sleep deprivation and amphetamine.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-24
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  20     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-03     Completed Date:  2012-09-14     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-81     Citation Subset:  IM    
Division of Immunology & Inflammation, Faculty of Medicine, Imperial College London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fluorescein Angiography
Glaucoma / diagnosis
Macular Edema / complications*,  diagnosis,  physiopathology
Middle Aged
Multicenter Studies as Topic
Panuveitis / etiology*,  physiopathology
Randomized Controlled Trials as Topic
Tomography, Optical Coherence
Uveitis, Intermediate / etiology*,  physiopathology
Visual Acuity / physiology*
Visual Fields / physiology
Visual Perception / physiology*
Grant Support
U10 EY 014655/EY/NEI NIH HHS; U10 EY 014656/EY/NEI NIH HHS; U10 EY 014660/EY/NEI NIH HHS; U10 EY014655/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hydroclimatological variability and dengue transmission in Dhaka, Bangladesh: a time-series study.
Next Document:  Current and Emerging Indications for Implantable Cardiac Monitors.